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Recruiting NCT06188767

Testosterone-induced Muscle Memory and Underlying Mechanisms

No phase Interventional Skeletal Muscle Physiology

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Testosterone Undecanoate.
Who it may be relevant to
Registry conditions: Skeletal Muscle Physiology. Basic parameters: 18 years — 40 years · Male.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Denmark
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Long-term Effects of Anabolic Androgenic Steroids on Muscle Growth Potential: Testosterone-induced Muscle Memory and Underlying Mechanisms

Overview

The purpose of this project is to investigate underlying mechanisms of testosterone- and resistance training-induced muscle hypertrophy and muscle memory in humans.

Interventions

  • Drug Testosterone Undecanoate
    Following testosterone/placebo injection, participants undergo supervised resistance training for 4 weeks. This period is followed by a washout period with no drug and either continued resistance training or detraining for 16 weeks. Thereafter, another 4-week period with supervised resistance training is commenced, with no drug.

Primary outcome measures

  • Fiber cross-sectional area [Time frame: The change in fiber cross-sectional is assessed at baseline, 4, 20 and 24 weeks]
  • Myonuclei [Time frame: The change in myonuclei is assessed at baseline, 4, 20 and 24 weeks]
  • Skeletal muscle proteome [Time frame: The change in the muscle proteome is assessed at baseline, 4, 20 and 24 weeks]
Secondary outcome measures (3)
  • Lean mass [Time frame: The change in lean mass is assessed at baseline, 4, 20 and 24 weeks]
  • Satellite cells [Time frame: The change in satellite cells is assessed at baseline, 4, 20 and 24 weeks]
  • Muscle strength [Time frame: The change in 1-repetition maximum is assessed at baseline, 4, 20 and 24 weeks]

Eligibility criteria

Inclusion criteria

  • Healthy men and women
  • BMI of <26 and normal ECG and blood pressure

Exclusion criteria

  • Smoking
  • Chronic disease,
  • Use of prescription medication
  • Pain due to current or previous musculoskeletal injury
  • Resistance training more than once per week in the 12 months leading up to the intervention
  • Current or previous use of prohibited anabolic substances

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Quadruple blind
Primary purpose
Basic science

Study locations

Denmark · 1 center
  • The August Krogh Section for Human and Molecular Physiology, Department of Nutrition, Exer — Copenhagen

Identifiers

NCT: NCT06188767 · TESTO

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗