Auditory Prediction and Error Evaluation in the Speech of Individuals Who Stutter
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Delaying speech initiation, Auditory errors and pre-speech auditory modulation, Contributions of the speech premotor cortex to pre-speech auditory modulation, Delaying auditory feedback.
- Who it may be relevant to
- Registry conditions: Healthy Subjects, Stuttering, Developmental. Basic parameters: from 3 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Stuttering negatively impacts communication and reduces the overall quality of life and well-being of individuals who stutter. This study will provide a strong foundation for developing neural and behavioral interventions for stuttering. Participants will be asked to name pictures, read words/sentences silently or aloud, and listen to speech and nonspeech sounds while their speech, muscle, and brain signals are collected. Some participants may also receive brain stimulation while reading and speaking.
Interventions
- Behavioral Delaying speech initiation
This intervention will examine the effects of misalignment between prediction and auditory feedback in participants. We will use transcranial magnetic stimulation to induce a temporal misalignment between prediction and auditory feedback while participants produce speech. - Behavioral Auditory errors and pre-speech auditory modulation
This intervention will examine the contributions of auditory errors to pre-speech auditory modulation. Participants will receive auditory perturbations while speaking, and we will collect their brain activities throughout the study. - Behavioral Contributions of the speech premotor cortex to pre-speech auditory modulation
This intervention will examine the effects of stimulation of the left ventral premotor cortex on pre-speech auditory modulation. Participants will receive electrical stimulation while speaking. - Behavioral Delaying auditory feedback
This intervention will examine the effects of misalignment between prediction and auditory feedback in participants. We will use delayed auditory feedback to induce a temporal misalignment between prediction and auditory feedback while participants produce speech.
Primary outcome measures
- Change in brain activity before and during speaking [Time frame: within each session of the study that may last up to 2 hours]
- change in speech when participants experience auditory errors [Time frame: within each session of the study that may last up to 2 hours]
Eligibility criteria
Inclusion criteria
- being a monolingual, native speaker of American English
- absence of developmental, psychological, neurological, or communication disorders (other than developmental stuttering) as confirmed by a certified research SLP
- normal (age-appropriate) binaural pure-tone hearing threshold (0.5-4k Hz; ≤25 dB HL for younger than 70 years, and ≤35 dB HL for older than 70 years)
- not taking any medications that affect the central nervous system
- absence of safety contra-indication for tDCS, TMS and MRI (for adults)
- scoring at the 20th percentile or higher on standardized speech-language tests (for children)
Exclusion criteria
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Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Double blind
- Primary purpose
- Basic science
Study locations
United States · 2 centers
- Arizona State University — Tempe
- Univeristy of Washington — Seattle
Identifiers
NCT: NCT06181149 · R01DC020162 · 1R01DC020162-01A1