Cardiac CT Angiography in Patients With Acute Ischemic Stroke
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Cardiac Computed Tomography Angiography.
- Who it may be relevant to
- Registry conditions: Acute Ischemic Stroke, Coronary Artery Disease. Basic parameters: from 40 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Assessment of Cardiac CT Angiography in Patients Undergoing Thrombectomy for Ischemic Stroke
Overview
Mortality rates after acute ischemic stroke remain high despite continuously improving treatment. In this context, it is important to note that a relevant portion of acute ischemic stroke patients die from adverse cardiovascular events, such as myocardial infarction, rather than from complications associated with the stroke itself. A possible reason might be that this patient group often suffers from at least moderate asymptomatic coronary artery disease. This study seeks to integrate cardiac computed tomography angiography into the standard-of-care diagnostic protocol of acute ischemic stroke. The aim of this prospective mono-centric trial is to enable accurate diagnosis of therapy-relevant coronary artery disease, other concomitant cardiac findings and cardiac causes of acute ischemic stroke, without delaying stroke therapy. In the long-run, the goal is to investigate whether cardiac computed tomography angiography and the resulting therapeutic measures (interventions or medications added) can improve functional outcome and rate of adverse cardiac complications in patients with acute ischemic stroke compared to a retrospective matched-cohort of patients without cardiac CT imaging.
Interventions
- Diagnostic test Cardiac Computed Tomography Angiography
Non-invasive imaging of the heart, the greater vessels and the coronary arteries using computed tomography.
Primary outcome measures
- Diagnosis of therapy-relevant CAD and concomitant cardiac findings resulting in new therapeutic measurements. [Time frame: 1 day at hospital discharge]
Secondary outcome measures (1)
- The rate of adverse cardiovascular events (MACE). [Time frame: 90 and 365 days]
Eligibility criteria
Inclusion criteria
- Patients aged 40 years or above, presenting at the Emergency Department of the University Medical Center Hamburg-Eppendorf with a suspected acute ischemic stroke and a relevant neurological deficit (NIHSS score > 4).
Exclusion criteria
- A causal differential diagnosis for the acute stroke syndrome with absent intracranial vessel occlusion.
- No correlation for the patients' symptoms in the cranial CTA (no vessel obstruction).
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT06176872 · 2022-100951-BO-ff