Effect of Nitrate Supplementation on Blood Pressure and Microvascular Function of Resistant Hypertensive Patients
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Beetroot extract, Placebo.
- Who it may be relevant to
- Registry conditions: Arterial Hypertension, Resistant Hypertension, Microvascular Function, Nitrate Supplementation. Basic parameters: 18 years — 75 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Brazil
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Effect of Nitrate Supplementation on Blood Pressure and Systemic Microvascular Function of Resistant Hypertensive Patients
Overview
Arterial hypertension (AH) has been identified as an important public health problem and considered a new epidemic with high mortality and morbidity. High blood pressure (BP) levels increase the chances of coronary artery disease (CAD), heart failure (HF), stroke, chronic renal failure (CRF) and death. Beetroot powder may be an easier way to increase the availability of nitric oxide and consequently vasodilation in these patients. However, studies are needed to evaluate its benefits in patients with AH.
Interventions
- Dietary supplement Beetroot extract
Beetroot extract powder supplementation with 400mg of nitrate per dose in the amount of 10g per day orally will be used in the group. - Dietary supplement Placebo
The placebo will be administered as a colored and flavored isocaloric supplement composed of maltodextrin.
Primary outcome measures
- Assessment of blood pressure evolution [Time frame: 60 days]
Eligibility criteria
Inclusion criteria
- Resistant hypertension, with a diagnosis described in the medical record, without changing medications or increasing doses in the last 30 days.
Exclusion criteria
- neoplasms
- heart failure
- use of medications with nitrate in their formula
- patients undergoing renal denervation
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Crossover
- Masking
- Quadruple blind
- Primary purpose
- Treatment
Study locations
Brazil · 1 center
- National Institute of Cardiology — Rio de Janeiro
Identifiers
NCT: NCT06169241 · 70847523.9.0000.5272