Number of Previous Cesarean Sections on the Results of Angiogenic Factors.
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: sFlt-1/PGIF.
- Who it may be relevant to
- Registry conditions: Cesarean Section. Basic parameters: from 18 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Panama
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Effect of Number of Previous Cesarean Sections on the Results of Angiogenic Factors. A Descriptive, Prospective Study.
Overview
Hypertensive disorders of pregnancy (HPT) are an important cause of maternal-feto-neonatal morbidity and mortality, being one of the three leading causes of maternal death in our country and in developing countries. The only cure for THE is termination of pregnancy, which ends up being a decision in which gestational age and maternal risks must be balanced. Angiogenic factors have come to occupy an indispensable place in the arsenal of tools that can be used to separate the patient with a high likelihood of complications from those in whom prolongation of pregnancy could represent an important neonatal benefit. Although the usefulness of angiogenic factors in these scenarios is known, little is known about the effects that other conditions might have on their serum levels, mainly those that have an effect on trophoblastic invasion, the process that initiates implantation of the pregnancy in the endometrium. The purpose of the present study is to assess the effect that a history of uterine surgery, such as caesarean section, might have on angiogenic factor scores in subjects with no history of a hypertensive disorder of pregnancy.
Interventions
- Diagnostic test sFlt-1/PGIF
Index of sFlt-1/PGIF
Primary outcome measures
- Index sFlt-1/PIGF [Time frame: From the moment of randomization up until delivery. Between 24-48 hours.]
Secondary outcome measures (1)
- Progression to preeclampsia [Time frame: Up until discharge. On average, 7 days]
Eligibility criteria
Inclusion criteria
- 36 weeks of gestation or more
- Singleton pregnancy
- Previous cesarean section (case)
Exclusion criteria
- Vasculitis
- Twin pregnancy
- Chronic endometritis
- Smoking
- Lupus
- Renal failure
- Liver disease
- Thrombocytopenia
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-control
Study locations
Panama · 1 center
- Saint Thomas H — Panama City
Identifiers
NCT: NCT06166303 · U1111-1301-2580