18F-MFBG Cardiac Imaging for Heart Failure Administration
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Standard medical care for heart failure.
- Who it may be relevant to
- Registry conditions: Rest Gated Myocardial Perfusion Imaging in Heart Failure. Basic parameters: 18 years — 80 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
18F-meta-fluorobenzylguanidine Cardiac Imaging for Evaluation of Chronic Heart Failure
Overview
The clinical feasibility of 18F-FMBG cardiac PET imaging will be observed in sympathetic nervous system activity in patients with heart failure, predicted cardiac events, guided ICD implantation, and evaluated therapy efficiency.
Detailed description
This is a prospective, single-center clinical study, using18F-meta-fluorobenzylguanidine (18F-MFBG) cardiac PET imaging to present the sympathetic nerve status in heart failure, including ICD implantation. Through follow-up, we analyze the correlation between the distribution of the tracer in the heart and the functions and progression of the patients, including the occurrence of ventricular arrhythmias and sudden cardiac death, And further investigate the guiding value of 18F-MFBG cardiac sympathetic nerve imaging in the screening of ICD implantation patients, including primary and secondary prevention, reducing the cost of ICD implantation and related complications. Furthermore, to evaluate the therapy efficacy for these patients with heart failure using 18F-MFBG cardiac imaging has been considered.
Interventions
- Diagnostic test Standard medical care for heart failure
Standard treatment and care for heart failure patients from the heart failure center of Sichuan Provincial People's Hospital.
Primary outcome measures
- observe the 18F-MFBG distribution of the myocardium in heart failure patients [Time frame: 1 year]
Eligibility criteria
Inclusion criteria
- 1\. Clinically confirmed patient with chronic heart failure, LVEF ≤ 40%, cardiac function NYHA 2-3 grade, survival period greater than 1 year, evaluated by the Heart Failure Center of Sichuan Provincial People's Hospital.
- 2\. Chronic heart failure patients were evaluated by the Cardiology Department of Sichuan Provincial People's Hospital 5-10 days before ICD implantation.
- 3\. All patients above have signed an informed consent form.
Exclusion criteria
- 1\. Heart failure, heart function NYHA levels ⅠOR Ⅳ.
- 2\. The patient has already implanted ICD or CRT.
- 3\. Heart transplant patients.
- 4\. Patients with malignant tumors.
- 5\. Heart valve disease.
- 6\. Myocardial infarction occurred within the past three months.
- 7\. The patient has contraindications for ICD implantation surgery.
- 8\. The patient does not cooperate or is unwilling to conduct the study.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-control
Study locations
China · 1 center
- Zhi Ling Ding — Chengdu
Identifiers
NCT: NCT06149195 · CMFBG202311