AvoCog - the Effect of Daily Avocado Intake on Cognitive Function in Older Adults
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Avocado Group.
- Who it may be relevant to
- Registry conditions: Brain Aging. Basic parameters: 65 years — 85 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
AvoCog - The Effect of Daily Avocado Intake on Cognitive Function in Older Adults
Overview
The goal of this clinical trial is to determine if adding avocados to the diet of impacts cognition in 70 older adults, age 65-85, without dementia. We will test for change in functional MRI, cognitive performance, and brain blood flow. Intervention group participants will be asked to consume 1 avocado per day for 12 weeks. Participants in the control group will be asked to continue their normal intake for 12 weeks. Throughout the study, participants will be asked to perform cognitive tests, MRI, blood tests, and questionnaires.
Interventions
- Other Avocado Group
Participants will consume provided avocados daily and track consumption for the duration of the study. Participants will be adding avocados to their diet and will receive education on maintaining usual diet.
Primary outcome measures
- Change in brain activity [Time frame: Baseline and 12 weeks]
Secondary outcome measures (2)
- Changes in cerebral blood flow [Time frame: Baseline and 12 weeks]
- Changes in memory and executive function [Time frame: Baseline and 12 weeks]
Eligibility criteria
Inclusion criteria
- Males and females aged 65-85 years
- Good general health with no concomitant disease
- BMI 18.5 - 35 kg/m2
- Mini Mental State Exam ≥26
- Reports consuming ≤2 medium avocados per month
- Reports consuming ≤3 servings of carotenoid-rich foods per week and ≤3 servings of fruits and vegetables per day
- Skin carotenoid content <400
Exclusion criteria
- Unwilling or unable to consume avocado
- Latex allergy
- Consistently taking lutein + zeaxanthin supplements
- Skin carotenoid content ≥400
- Central neurological disease such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, stroke, brain tumor, etc.
- Serious medical risk: cancer requiring chemotherapy or radiation within the past 5 years, recent cardiac event (i.e. heart attack, etc.)
- Diabetes mellitus or uncontrolled hypertension
- Use of psychoactive or investigational medications
- Consumption of ≥3 alcoholic drinks per day or substance abuse
- Unable to undergo MRI
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Double blind
- Primary purpose
- Prevention
Study locations
United States · 1 center
- University of Kansas Medical Center — Kansas City
Identifiers
NCT: NCT06137339 · 00150975