Recruiting NCT06129799
Exercise CMR in (p)LF-LG AS
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Aortic Stenosis, Severe. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Germany
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Exercise CMR in (Paradoxical) Low-flow Low-gradient Aortic Stenosis
Overview
Patient with paradoxical or conventional low-flow low-gradient aortic stenosis on echocardiographic assessment will undergo physiological exercise-stress CMR in addition to guideline recommended surveys prior to TAVR.
Primary outcome measures
- Composite of events: number of participants with cardiovascular death or heart failure hospitalisation [Time frame: 12 months]
Eligibility criteria
Inclusion criteria
- paradoxical or conventional severe low-flow low-gradient aortic stenosis
Exclusion criteria
- CMR incapable device
- unable to undergo 40 min scan (can not lie flat, claustrophobia)
- renal insufficiency (eGFR <30 ml/min/1.73m²)
- allergy against contrast agent
- unable to exercise in supine position
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-control
Study locations
Germany · 1 center
- University Hospital Goettingen — Göttingen
Identifiers
NCT: NCT06129799 · 16822