Basal Instincts: Towards Better Understanding of Basal Cell Function in Chronic Rhinosinusitis With Nasal Polyps
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Conchotomy, aesthetic nose surgery or functional endoscopic sinus operation.
- Who it may be relevant to
- Registry conditions: Chronic Rhinosinusitis With Nasal Polyps, Allergic Rhinitis. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Belgium
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
During this project, the investigators want to explore in vitro changes in basal cells and the crosstalk with residing immune cells as potential pathogenic mechanisms in CRSwNP vs healthy controls by using surgically resected patient samples.
Detailed description
The investigators want to use patient and healthy control samples to study/compare the following aspects in vitro:
1. Investigate differences in epithelial and basal cell functions and differentiation characteristics. 2. Characterize the differences in epithelial cell populations and gene expression patterns. Also include an AR subset, to see if changes are specific for CRSwNP or more general for type 2 inflammatory disease of the upper airways. 3. Investigate basal cell activation via different environmental triggers through TLR stimulation. 4. Look at the genetic imprinting of basal cells before and after being exposed to specific triggers. 5. Investigate whether the secreted proteins from basal cells are chemotactic for other cell populations. 6. Investigate the interaction between basal and regulatory T cells.
Interventions
- Procedure Conchotomy, aesthetic nose surgery or functional endoscopic sinus operation
Conchotomy involves the reduction or removal of hypertrophic nasal turbinates, aesthetic nose surgery is a surgical procedure that aims to enhance the appearance of the nose, while functional endoscopic sinus surgery is a minimally invasive procedure focused on treating sinus conditions by removing obstructions and improving sinus drainage.
Primary outcome measures
- Functional differences between epithelial/basal cells from CRSwNP samples in comparison to healthy controls assessed with functional assays. [Time frame: 12-24 months]
- Characterization of differences in gene expression profiles and epithelial populations in/between CRSwNP and healthy controls assessed with different sequencing techniques. [Time frame: 9-18 months]
- Changes and interactions in the basal and regulatory T-cell axis between healthy and CRSwNP-isolated cells will be studied through co-culture experiments. [Time frame: 9-18 months]
Eligibility criteria
Inclusion criteria
- Patients over the age of 18
- Males and females
Exclusion criteria
- CRSwNP
- AR
- Smoker, or < 1-year ex-smoker
- Underlying systematic pathology (Morbus Wegener or Churg Strauss Syndrome for example)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
Belgium · 1 center
- Peter Hellings — Leuven
Identifiers
NCT: NCT06129552 · S67788