Phase 3, Multi-center, Prospective, Randomized, Double-blind, Placebo- Controlled Study to Evaluate the Effectiveness and Safety of ZP5-9676 for the Treatment of Soil Transmitted Helminthiasis (STH)
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: ZP5-9676 600 mg dose, Placebo.
- Who it may be relevant to
- Registry conditions: Soil-Transmitted Helminthiasis (STH). Basic parameters: 6 months — 59 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Brazil
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
A Phase 3, Multi-center, Prospective, Randomized, Double-blind, Placebo- Controlled Study to Evaluate the Effectiveness and Safety of ZP5-9676 for the Treatment of Hookworm (Ancylostoma Duodenale and Necator Americanus), Ascaris Lumbricoides, and Trichuris Trichiura in Pediatric and Adult Participants
Overview
This is a Phase 3, multi-center, prospective, randomized, double-blind, placebo-controlled study to evaluate the effectiveness, safety, and tolerability of ZP5-9676 compared to placebo for the treatment of STH infections. Approximately 300 participants will be enrolled, randomized at the Baseline visit (Day 1) to one of the following treatments in a 1:1 ratio of active and placebo.
Detailed description
Approximately 300 infected participants will be enrolled to ensure that there is a minimum of 114 hookworm-infected participants evaluable for the Test of Cure study visit (Day 14). Some participants may be co-infected and will be included in each tally.
Participants will be randomized (1:1) to one of the treatments below followed by standard of care treatment:
* Treatment A: ZP5-9676 600 mg dose * Treatment B: Placebo
Interventions
- Drug ZP5-9676 600 mg dose
oral, chewable tablet formulation of flubendazole - Drug Placebo
Matching placebo
Primary outcome measures
- Cure rates [Time frame: 14 days]
Secondary outcome measures (2)
- Egg reduction [Time frame: 14 days]
- Cure rates [Time frame: 14 days]
Eligibility criteria
Inclusion criteria
- Provide a signed informed consent form from the participant or parent/guardian, and assent by participant(as applicable per local requirements) and understand and agree to comply with required procedures in the study.
- Male or female, who are 6 months to 59 years old, inclusive, and live in a high STH prevalence area
- Positive for hookworm (A. duodenale or N. americanus), A. lumbricoides, and/or T. trichiura on microscopic examination of fecal samples.
- Females of childbearing potential must use an acceptable method of contraception as determined by the Investigator from the initial Screening visit through 35 days after study drug administration. A female is considered to be of childbearing potential from menarche until after menopause (age >45 years with no menses for 12 months without an alternative medical cause) unless permanently sterile. Acceptable methods include abstinence, hormonal contraceptives, intrauterine device/system, vasectomy in the sole male sexual partner, tubal ligation, or double-barrier contraceptive method (male condom with female cervical cap, diaphragm, or sponge) with spermicide.
- Otherwise healthy based on medical history, physical examination, vital signs, and concomitant medications for inclusion.
Exclusion criteria
- Severe anemia (hemoglobin< 8 g/dL1).
- Active diarrhea (passage of ≥3 loose or liquid stools per day).
- Children (6 months to 17 years old) with significant wasting (moderate and severe-below minus two standard deviations from median weight for height of reference population).
- Women who are pregnant.
- Hypersensitivity or allergy to ZP5-9676 or any inert ingredients in the chewable formulation or other medications in the benzimidazole class.
- Taken ZP5-9676 or any other treatment for STH infection within 30 days of screening or randomization.
- Used an investigational medical device within 30 days of screening.
- Preplanned surgery procedures within 30 days of screening.
- History of a medical disorder causing difficulty in chewing or swallowing.
- Participation in any investigational drug (including vaccine) trial within 30 days or six half-lives of the test drug's biologic activity, whichever is longer, before the start of the study (time of first dose).
- Participation in an interventional clinical study within 30 days of screening.
- Any condition that interferes with the ability to understand or comply with the requirements of the study.
- Any other medical condition, serious illness, or other circumstance that would place the subject at increased risk, as determined by the Investigator
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Triple blind
- Primary purpose
- Treatment
Study locations
Brazil · 1 center
- Clínica de Vacinas — Americaninha
Identifiers
NCT: NCT06128447 · ZP5-9676-301