Systems Oncology Approach to Optimize Ovarian Cancer Treatment
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Biomolecular profiling.
- Who it may be relevant to
- Registry conditions: Ovarian Cancer. Basic parameters: No limits · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Finland
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
The overall aim is to identify effective therapeutic strategies to ovarian cancer (OC) using serial tumor, ascites and blood samples, and carry out state-of-the-art sequencing approaches, functional assays and associated bioinformatics to understand mechanisms behind chemoresistance in OC and identify new treatment options for OC patients. In this observational trial, we will systematically collect, analyze and interpret functional, molecular and clinical data from real-world ovarian cancer patients.
Interventions
- Genetic Biomolecular profiling
Molecular and functional analysis of biospecimens, including tumor-normal Whole-exome sequencing, bulk and single-cell RNAsequencing, spatial proteomics, functional testing.
Primary outcome measures
- Recruitment and collection of real-world clinical data from ovarian cancer patients [Time frame: 5 years]
- Successful collection and translational analysis of biospecimens [Time frame: 5 years]
Secondary outcome measures (1)
- Discovery of candidate prognostic and predictive biomarkers [Time frame: 5 years]
Eligibility criteria
Inclusion criteria
- Patients diagnosed with ovarian cancer
- Available tumor tissue/blood samples
Exclusion criteria
- Inability to consent to the study
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Finland · 1 center
- Helsinki University and Helsinki University Hospital — Helsinki
Identifiers
NCT: NCT06117384 · HUS33342021