Long-term Neurovascular Complications After Radiation Therapy in Head and Neck Cancer
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Radiation Treatment, Neurovascular Complications. Basic parameters: 20 years — 100 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Taiwan
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
The Ambidirectional Cohort Study of Neurovascular Complications After Radiation Therapy in Head and Neck Cancer Patients
Overview
Head and neck cancer is a group of cancers develop from the soft tissues, salivary gland, mucosa of the upper respiratory or digestive system covering the oral and nasal cavity. Radiotherapy is usually the standard treatment of Head and neck cancers. In the present study, investigators aim to study the prevalence of cervical-cranial vascular complications during the early stages in these Head and neck cancer patients receiving Radiotherapy. Investigators will also compare the results between Nasopharyngeal cancer and other Head and neck cancerpatients receiving Radiotherapy.
Primary outcome measures
- Significant CAS at internal carotid artery or common carotid artery [Time frame: 1 year]
- Cerebral infarctions (CI) [Time frame: 1 year]
- Significant extracranial vertebral artery stenosis (VAS) [Time frame: 1 year]
- Significant intracranial artery stenosis [Time frame: 1 year]
- Presence of carotid blow-out syndrome [Time frame: 1 year]
- Presence of TLN [Time frame: 1 year]
- Presence of hypothyroidism [Time frame: 1 year]
- Tumor recurrence [Time frame: 1 year]
- Mortality [Time frame: 1 year]
Eligibility criteria
Population: Prospective cohort
Inclusion criteria
- Age ≥20 years.
- Head and neck cancer patient .
- Had ever received radiation therapy (RT) ≦ 72 months before inclusion in the registry.
- Had ≥ 1 brain images and cervical-cranial vascular studies between the end of RT and d date of enrolment.
Exclusion criteria
- Age <20 years.
- Patients not willing to sign the informed consent.
Population: Retrospective validation cohort
Inclusion criteria
- Age ≥20 years.
- Head and neck cancer patient.
- Had ever received radiation therapy (RT) > 120 months before the adoption date of IRB at the participant site.
- Had ≥ 2 brain images and cervical-cranial vascular studies between the end of RT and 6\~10 years after RT, one within 5 years after RT, the other after 5 years after RT.
Exclusion criteria
1.Age <20 years.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Taiwan · 1 center
- Chang Gung Memorial Hospital — Taipei
Publications
- Jiang JL, Chang JT, Huang BS, Chang TY, Sung PS, Wei YC, Lin CY, Yeh CH, Fan KH, Liu CH. Post-irradiation vertebral and carotid stenosis heightens stroke risk in head and neck cancer. BMC Cancer. 2025 Feb 11;25(1):235. doi: 10.1186/s12885-025-13647-6. PMID 39934712
Identifiers
NCT: NCT06111430 · 202200464B0