Looking for a Blood Epigenetic Signature to Predict Female Infertility
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: search for epigenetic profile of infertility.
- Who it may be relevant to
- Registry conditions: Female Infertility. Basic parameters: 18 years — 43 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Italy
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The present research project aims to study the DNAm mechanisms underlying the reduction of fertility due to the progressive depletion of oocyte quality. Specifically, our project aims to build an epigenetic clock for MGCs by using outcomes that are certainly related to female fertility. The validation of such findings will be carried out on peripheral blood in order to guarantee its non-invasiveness and allow for any clinical transferability. In order to identify a blood epigenetic signature able to predict female infertility, we planned to explore the problem from different points of view by conducting several studies in different settings.
Interventions
- Genetic search for epigenetic profile of infertility
examine the epigenetic profile of DNA extracted from MGCs and blood sample
Primary outcome measures
- differences of DNA methylation in granulosa cells of patients undergoing ART [Time frame: 3 years]
- differences of DNA methylationin the peripheral venous blood of patients undergoing ART [Time frame: 3 years]
- differences of DNA methylationin the peripheral venous blood of women attempting to conceive naturally [Time frame: 3 years]
- differences of DNA methylationin the peripheral venous blood of new patients undergoing ART [Time frame: 3 years]
- impact of exogenous pro-inflammatory factors [Time frame: 3 years]
Eligibility criteria
Inclusion criteria
- 18< age <43, Infertile woman undergoing ART, recurrent pregnancy loss
Exclusion criteria
- age < 18 or > 44, previous ovarian surgery, severe male factor infertility
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
Italy · 1 center
- Università Vita Salute San Raffaele — Milan
Identifiers
NCT: NCT06098495 · FIB_CARIPLO_1.0