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Recruiting NCT06096233

Effect of Exercise on Appetite in Response to Meals

No phase Interventional Healthy

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Bouts of Exercise.
Who it may be relevant to
Registry conditions: Healthy. Basic parameters: 18 years — 65 years · Male.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United Kingdom
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Acute Effect of Exercise on Post-meal Appetite, Appetite-Regulatory Hormones, and Energy Intake in Healthy Men

Overview

This clinical trial's primary aim is to investigate the acute effect of two exercise bouts (short \[10 minutes\] and long \[30 minutes\]) on appetite and appetite-regulatory hormone responses to a standard meal test. The secondary aim is to investigate when the changes in appetite and appetite-regulatory hormones occur during exercise. As an exploratory aim, the researchers will test if the two exercise bouts influence ad libitum energy intake in the periods after the standard meal test. The researchers will compare three groups (control, short exercise, and prolonged exercise) to see if the exercise bouts affect appetite, appetite-regulatory hormones, and energy intake in healthy men.

Detailed description

Study Design

Screening visit Before conducting the main experiments, the participants will attend a screening visit where consent will be obtained, and they will complete questionnaires to assess health, food preferences, and physical activity. The researchers will then measure the participants' height, weight, waist circumference, and body composition.

After the researchers confirm the eligibility criteria, participants will take part in two treadmill tests to establish maximum oxygen uptake test (V̇O2 max) (Broom et al. 2017).

Experimental design After the screening visit, the participants will complete three main experiments (control, short high-intensity exercise, and prolonged high-intensity exercise) in a counter-balanced design. All experiments began at \~0930, following an overnight fast of at least 10 hours. Participants will consume a prescribed meal in the evening before each main experiment. Following this meal, participants are only allowed to drink water until the start of the main experiments.

At the beginning of the exercise conditions, participants will run on the treadmill for 10 minutes (short) or 30 minutes (prolonged) at a speed estimated to elicit a 75% V̇O2 peak, followed by rest in the laboratory. In the control condition, the researchers will follow the same protocols except that the participants will not perform any exercise. The participants will have a standardized meal after exercise and then an ad libitum buffet meal afterward.

During each experiment, the researchers will assess appetite ratings using 100 mm visual analog scales (Flint et al. 2000). The researchers will also collect blood samples to examine ghrelin, peptide YY, glucagon-like peptide 1, and possibly other blood-borne measures.

Interventions

  • Other Bouts of Exercise
    The participants will run on the treadmill for 10 minutes (short) or 30 minutes (prolonged).

Primary outcome measures

  • Change in Peptide-YY (PYY) [Time frame: At 0 (baseline), 0.167, 0.5, 1, 1.5, 2, 3, and 4 hours]
  • Change in Ghrelin [Time frame: At 0 (baseline), 0.167, 0.5, 1, 1.5, 2, 3, and 4 hours]
  • Change in Glucagon-Like Peptide-1 (GLP-1) [Time frame: At 0 (baseline), 0.167, 0.5, 1, 1.5, 2, 3, and 4 hours]
  • Change in subjective appetite sensations [Time frame: At 0 (baseline), 0.167, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 5.5, and 6 hours]
Secondary outcome measures (2)
  • Energy Intake [Time frame: At 5 hours]
  • Macro-nutrient Intake [Time frame: At 5 hours]

Eligibility criteria

Inclusion criteria

  • Males aged 18 years or older.
  • Have stable body mass for at least six months (within ±2 kg).

Exclusion criteria

  • Females
  • People who are younger than 18 or older than 65 years old.
  • Have food allergies.
  • Have significant contraindications to exercise (e.g., an injury that would inhibit running).
  • Smoking.
  • Suffering from metabolic health issues, e.g., history of diabetes, cardiovascular disease, or eating disorders.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
Randomized
Model
Crossover
Masking
Open label
Primary purpose
Basic science

Study locations

United Kingdom · 1 center
  • New Lister Building at Glasgow Royal Infirmary — Glasgow

Publications

  • Broom DR, Miyashita M, Wasse LK, Pulsford R, King JA, Thackray AE, Stensel DJ. Acute effect of exercise intensity and duration on acylated ghrelin and hunger in men. J Endocrinol. 2017 Mar;232(3):411-422. doi: 10.1530/JOE-16-0561. Epub 2016 Dec 20. PMID 27999089
  • Flint A, Raben A, Blundell JE, Astrup A. Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. Int J Obes Relat Metab Disord. 2000 Jan;24(1):38-48. doi: 10.1038/sj.ijo.0801083. PMID 10702749

Identifiers

NCT: NCT06096233 · 200220449

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗