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Recruiting NCT06093464

Beneficial Exposome Study

No phase Interventional Healthy

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Natural Compound A (Hinoki essential oil), Natural Compound B (Lemon essential oil), Natural Compound C (Control/Water).
Who it may be relevant to
Registry conditions: Healthy. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United States
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Beneficial Exposome: Investigating Its Effect on Human Health

Overview

The purpose of this study is to explore the positive, holistic health outcomes resulting from regular exposure to naturally occurring compounds predicted to have health benefits. The researchers hope to learn how the human body is influenced by regular exposure to these compounds.

Detailed description

Considerable research has been conducted on the effects of environmental exposure on human diseases. This is also known as "exposome" research. However, there is limited research on the impact of beneficial exposomes found in the natural environment. The researchers would like to identify and measure the benefits of these naturally occurring compounds on holistic human health.

Through blood specimens, the researchers will observe biomarkers such as cortisol levels and inflammatory markers. Data will be collected from wearable sensors to observe the effects of beneficial exposomes on areas such as cardiovascular health and sleep quality. There will be surveys to understand well-being, stress, and mood. Through such observations, this study aims to understand the positive impacts of intentional exposure to selected compounds found in nature.

Interventions

  • Other Natural Compound A (Hinoki essential oil)
    Participants will use "Natural Compound A" in a diffuser every night for 4 weeks. Diffuser will be placed near participant's bed and will be used during the entire time they are asleep (about 8 hours, every night).
  • Other Natural Compound B (Lemon essential oil)
    Participants will use "Natural Compound B" in a diffuser every night for 4 weeks. Diffuser will be placed near participant's bed and will be used during the entire time they are asleep (about 8 hours, every night).
  • Other Natural Compound C (Control/Water)
    Participants will use "Natural Compound C" in a diffuser every night for 4 weeks. Diffuser will be placed near participant's bed and will be used during the entire time they are asleep (about 8 hours, every night).

Primary outcome measures

  • Resting Heart Rate [Time frame: Baseline; 26 weeks]
  • Heart Rate Variability [Time frame: Baseline; 26 weeks]
  • Change in sleep quality measured as duration of sleep stages [Time frame: Baseline; 26 weeks]
  • Profile of Mood States [Time frame: Baseline; weeks 2, 6, 10, 14, 18, 22, and 26]
Secondary outcome measures (8)
  • Metabolome [Time frame: Baseline; weeks 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, and 26]
  • Proteome [Time frame: Baseline; weeks 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, and 26]
  • Transcriptome [Time frame: Baseline; weeks 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, and 26]
  • Well-being [Time frame: Baseline; weeks 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, and 26]
  • Perceived Stress [Time frame: Baseline; weeks 2, 6, 10, 14, 18, 22, and 26]
  • Generalized Anxiety [Time frame: Baseline; weeks 2, 6, 10, 14, 18, 22, and 26]
  • Depression [Time frame: Baseline; weeks 2, 6, 10, 14, 18, 22, and 26]
  • Inflammation Profile [Time frame: Baseline; weeks 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, and 26]

Eligibility criteria

Inclusion criteria

  • 18 years of age and older
  • Read, speak, and understand English
  • Live in the US territory

Exclusion criteria

  • Mental incapacity and/or cognitive impairment on the part of the patient that would preclude adequate understanding of, or cooperation with, the study protocol
  • Is pregnant
  • Is breastfeeding
  • Has epilepsy
  • Has allergies to Cupressaceae family of plants, common plants include redwoods, junipers, cypress, cedar, fir, and sequoia

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
Randomized
Model
Crossover
Masking
Open label
Primary purpose
Other

Study locations

United States · 1 center
  • Stanford University — Palo Alto

Identifiers

NCT: NCT06093464 · 71135

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗