Risk Markers of Arterial Aging. The Paris Prospective Study III-2
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: high-precision carotid echo-tracking.
- Who it may be relevant to
- Registry conditions: Arterial Stiffness. Basic parameters: 60 years — 95 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Risk Markers of Arterial Aging and Subsequent Risk of Cardiovascular Diseases and Beyond. The Paris Prospective Study III-2
Overview
The main objectives of PPS3-2 are (i) to describe the dynamics of vascular aging and baroreflex sensitivity 12 to 16 years a part, (ii) to identify their determinants, and (iii) to quantify the subsequent risk of cardiovascular diseases.
Detailed description
Since May 2008, PPS3 is being following the CVD morbidity of 10157 healthy volunteers aged 50-75 years at baseline. In PPS3-2, we plan to re-invite survivors and volunteers of PPS3 to undergo a second physical examination. In particular, they will undergo a second high-precision carotid echotracking to measure vascular aging parameters and baroreflex sensitivity, permitting to study their respective dynamics. They will also underwent for the first time ultra fast echo of the radial artery to measure vascular aging parameters of the medium-sized arteries. According to fundings, blood samples will be taken and stored at -80°C in the whole population or in a subsample.
Interventions
- Other high-precision carotid echo-tracking
evaluation of vascular aging parameters and baroreflex sensitivity
Primary outcome measures
- carotid diameter [Time frame: by 2027]
- intima media thickness [Time frame: by 2027]
- carotid plaques [Time frame: by 2027]
- wall cross sectional area [Time frame: by 2027]
- distensibility coefficient [Time frame: by 2027]
- elastic modulus [Time frame: by 2027]
- pulse wave velocity [Time frame: by 2027]
- carotid wall stress [Time frame: by 2027]
- stiffness [Time frame: by 2027]
- pulse pressure [Time frame: by 2027]
Secondary outcome measures (10)
- brachial artery diameter [Time frame: by 2027]
- thickness of the intima media of the radial artery [Time frame: by 2027]
- arterial plaques [Time frame: by 2027]
- wall cross sectional area of the radial artery [Time frame: by 2027]
- distensibility of the radial artery [Time frame: by 2027]
- elastic modulus of the radial artery [Time frame: by 2027]
- pulse wave velocity of the radial artery [Time frame: by 2027]
- stiffness index of the radial artery [Time frame: by 2027]
- wall stress of the radial artery [Time frame: by 2027]
- pulse pressure of the radial artery [Time frame: by 2027]
Eligibility criteria
Inclusion criteria
- Being enrolled in PPS3 and having signed an informed consent for PPS3-2
Exclusion criteria
- Institutionalized participants
- Participants under guardianship
- Participants under judicial safeguard measure
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
France · 1 center
- Centre d'Investigation Précliniques — Paris
Identifiers
NCT: NCT06079424 · C21-67