Impact of Pre-Military Life Experiences/Exposures on Active-Duty Service Members' Psychological Health
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Traumatic Brain Injury. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Impact of Pre-Military Life Experiences/Exposures on Active-Duty Service Members' Psychological Health and Adjustment Over a Marine Battalion Deployment Cycle
Overview
The goal of this observational study is to learn about the impact of historic and current Traumatic Brain Injuries on a Marine Battalion. Its main objectives are: * Establish individual mental and physical performance profile and brain health baseline in Infantry Marines * Develop predictive models to identify early signs of mental and/or physical degradation that can help predict "red-line" behavioral events and degradation in brain health. * Gather insights that will lead to developing personalized, evidence-based interventions to restore mental and physical performance. * Increase warfighter self-knowledge and personal awareness to monitor and maximize performance. Participants will wear wear smart watches and analyte sensors to track their real time physiological and sleep measures and complete subjective and psychological measures in a custom research app.
Detailed description
To prevent brain health degradation, it is necessary to understand the factors that contribute to brain insult and injury. The investigators aim to understand and identify pre-exposure risk, reversible and irreversible injury, and the impact of stressors. The investigators will research the real-time interaction between exposure and injury biomarkers and identify how the interaction affects long-term health and measures such as time to recovery.
The project will work with a newly formed Infantry Marine Battalion on Camp Pendleton. This group of Service Members will have many that are beginning their military careers, and thus will bring in only the components of brain health and emotional trauma they have accumulated during their civilian lives to this point.
Participants will be provided with a customized research mobile application that will obtain baseline information related to their military history and experience, and then continuously track activity, physiologic parameters, sleep, cognition and emotional state. Detailed dietary consumption and metabolic data, if indicated, will be tracked and displayed. The data will be collected continuously
During the study, participants will be provided with their data in real-time and this will be displayed along with their schedule and tasks. During and upon completion of the study investigators will provide a detailed summary and analysis of their health and human performance metrics, including insights on how diet and activity impacts their metabolic control or other biomarkers and how all of these factors impact sleep, cognition and behavioral state. The investigators will collaborate with the participants to identify the most useful data displays and information that will best help them achieve optimized physical, mental and cognitive training and recovery and gain understanding of how metabolic control or other biomarkers impact these metrics.
These insights will be used to develop insight dashboards on the holistic health metrics mentioned above, and help provide optimization insights. We will work with participants to create additional app content specific for them that relates to optimal diet and mental and physical training and recovery.
Primary outcome measures
- Explanation of Outcomes [Time frame: 18 months]
- Establish individual mental and physical performance profile and brain health baseline in Infantry Marines. [Time frame: 1 month]
- Develop predictive models [Time frame: 18 months]
- Increase warfighter self-knowledge and personal awareness [Time frame: 18 months]
Eligibility criteria
Inclusion criteria
- Members of the 1st Marine Division 1st Battalion
Exclusion criteria
- None
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Other
Study locations
United States · 1 center
- Camp Pendleton — Oceanside
Publications
- Beckner ME, Main L, Tait JL, Martin BJ, Conkright WR, Nindl BC. Circulating biomarkers associated with performance and resilience during military operational stress. Eur J Sport Sci. 2022 Jan;22(1):72-86. doi: 10.1080/17461391.2021.1962983. Epub 2021 Aug 17. PMID 34346851
- Bollyky JB, Bravata D, Yang J, Williamson M, Schneider J. Remote Lifestyle Coaching Plus a Connected Glucose Meter with Certified Diabetes Educator Support Improves Glucose and Weight Loss for People with Type 2 Diabetes. J Diabetes Res. 2018 May 16;2018:3961730. doi: 10.1155/2018/3961730. eCollection 2018. PMID 29888288
- Brynes AE, Adamson J, Dornhorst A, Frost GS. The beneficial effect of a diet with low glycaemic index on 24 h glucose profiles in healthy young people as assessed by continuous glucose monitoring. Br J Nutr. 2005 Feb;93(2):179-82. doi: 10.1079/bjn20041318. PMID 15788110
- Cauza E, Hanusch-Enserer U, Strasser B, Kostner K, Dunky A, Haber P. Strength and endurance training lead to different post exercise glucose profiles in diabetic participants using a continuous subcutaneous glucose monitoring system. Eur J Clin Invest. 2005 Dec;35(12):745-51. doi: 10.1111/j.1365-2362.2005.01573.x. PMID 16313250
- Eslam M, Sarin SK, Wong VW, Fan JG, Kawaguchi T, Ahn SH, Zheng MH, Shiha G, Yilmaz Y, Gani R, Alam S, Dan YY, Kao JH, Hamid S, Cua IH, Chan WK, Payawal D, Tan SS, Tanwandee T, Adams LA, Kumar M, Omata M, George J. The Asian Pacific Association for the Study of the Liver clinical practice guidelines for the diagnosis and management of metabolic associated fatty liver disease. Hepatol Int. 2020 Dec; PMID 33006093
- Freckmann G, Hagenlocher S, Baumstark A, Jendrike N, Gillen RC, Rossner K, Haug C. Continuous glucose profiles in healthy subjects under everyday life conditions and after different meals. J Diabetes Sci Technol. 2007 Sep;1(5):695-703. doi: 10.1177/193229680700100513. PMID 19885137
- Gambhir SS, Ge TJ, Vermesh O, Spitler R, Gold GE. Continuous health monitoring: An opportunity for precision health. Sci Transl Med. 2021 Jun 9;13(597):eabe5383. doi: 10.1126/scitranslmed.abe5383. PMID 34108250
- Garcia-Compean D, Jaquez-Quintana JO, Gonzalez-Gonzalez JA, Lavalle-Gonzalez FJ, Villarreal-Perez JZ, Maldonado-Garza HJ. [Diabetes in liver cirrhosis]. Gastroenterol Hepatol. 2013 Aug-Sep;36(7):473-82. doi: 10.1016/j.gastrohep.2013.01.012. Epub 2013 Apr 28. Spanish. PMID 23628170
Identifiers
NCT: NCT06070025 · Brain Health Marine Btln · W81XWH-22-1-0956