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Recruiting NCT06047717

Vision Loss Impact on Navigation in Virtual Reality

No phase Interventional Stroke, Ischemic Quadrantanopia Hemianopsia, Homonymous Hemianopia, Homonymous

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Virtual Reality Driving Task.
Who it may be relevant to
Registry conditions: Stroke, Ischemic, Quadrantanopia, Hemianopsia, Homonymous, Hemianopia, Homonymous. Basic parameters: 21 years — 75 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United States
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

The Impact of Vision Loss on Naturalistic Behavior and Navigation in Virtual Reality

Overview

The purpose of this research is to better understand the impact of cortically-induced blindness (CB) and the compensatory strategies subjects with this condition may develop on naturalistic behaviors, specifically, driving. Using a novel Virtual Reality (VR) program, the researchers will gather data on steering behavior in a variety of simulated naturalistic environments. Through the combined use of computer vision, deep learning, and gaze-contingent manipulations of the visual field, this work will test the central hypothesis that changes to visually guided steering behaviors in CB are a consequence of changes to the visual sampling and processing of task-related motion information (i.e., optic flow).

Interventions

  • Other Virtual Reality Driving Task
    Participants will steer a virtual car with the goal of staying in the center of a single-lane roadway while traveling at a constant speed of 26.6 m/s (approximately 60 miles/hr). The roadway alternates between a series of straights and turns of different radii to both the left and the right. This allows for careful control of task difficulty, and for the repeated presentation of specific conditions across multiple "trials" (i.e. turns in the road) in a randomized order. In addition, the density

Primary outcome measures

  • Virtual Reality (VR) Lane Deviation / Offset [Time frame: Day 0]

Eligibility criteria

Cortically Blind Group:

Inclusion criteria

  • Residents of the United States or Canada
  • Presence of one-sided stroke or stroke-like damage to primary visual cortex or its immediate afferent white matter sustained within the specified age range of 21 - 75 years (verified by MRI and/or CT scans)
  • Reliable visual field defects in both eyes (homonymous defects) as measured by Humphrey or equivalent perimetry.
  • Willing, able, and competent to provide their own informed consent
  • Cognitively able, responsible to understand written and oral instructions in English
  • Emmetropic or else wear corrective contact lenses inside the virtual reality headset

Exclusion criteria

  • Those who have never driven or earned a drivers' license
  • Past or present ocular disease interfering with visual acuity
  • Best corrected visual acuity (BCVA) worse than 20/40 in either eye
  • Sustained damage to the dorsal lateral geniculate nucleus
  • Presence of diffuse, whole-brain degenerative processes
  • Presence of brain damage deemed by study staff to potentially interfere with outcome measures
  • History of traumatic brain injury
  • Documented history of drug/alcohol abuse
  • Diagnosis of cognitive or seizure disorders
  • Diagnosis of one-sided attentional neglect

Control Group:

Inclusion criteria

  • Normal or corrected-to-normal vision, who are between the ages of 21 and 75 years of age, roughly matched to the age of CB subjects enrolled above
  • Competent and responsible, as determined by the Principal Investigator
  • Willing, able, and competent to provide their own informed consent
  • Normal cognitive abilities, be able to understand written and oral instructions in English
  • Emmetropic or else wear corrective contact lenses inside the virtual reality headset

Exclusion criteria

  • Subjects who have never driven or earned a drivers' license
  • BCVA worse than 20/40 in either eye
  • Presence of vision loss from ocular diseases or disorders
  • Presence of a visual field defect
  • Inability to wear corrective contact lenses inside the virtual reality helmet if required to see clearly
  • Subjects with a history of neurological disorders
  • Subjects with a history of TBI
  • Persons who lack the competence or are otherwise unable to perform the visual testing as directed.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
Non-randomized
Model
Parallel assignment
Masking
Open label
Primary purpose
Basic science

Study locations

United States · 1 center
  • University of Rochester — Rochester

Identifiers

NCT: NCT06047717 · 00008669

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗