Eccentric Resistance Training Among Individuals With Chronic Heart Failure

Official title

Effects of Eccentric Resistance Training on Ventricle Functions and Aerobic Capacity Among Individuals With Chronic Heart Failure

Overview

To determine the effects of eccentric resistive training on ventricle functions and aerobic capacity as compared to a resistance and aerobic training among Heart failure (HF)

Interventions

• Other Eccentric Resistive Training + Aerobic training Group
  Eccentric Resistive training includes upper limb (biceps and triceps) and lower limb large muscle training (quadriceps and hamstrings) 2 sets of 12 repetitions (reps) for each group of muscles in lengthened position for eccentric training in approx. 20 minutes (min). Intensity will be based on 1 repetition maximum (1RM) starting from 20% of (1RM) and its intensity in percentage will be progress by 10% after every two weeks. Stair descending training and squatting position and eccentric hamstring
• Other Resistance Training + Aerobic training Group
  Resistive training (concentric) includes Upper limb (biceps and triceps) and lower limb large muscle training (quadriceps and hamstrings), 2 sets of 12 reps for each group of muscles in approx. 30 min. Intensity will be based on 1 repetition maximum (1RM) starting from 20% of (1RM) and its intensity in percentage will be progress by 10% after every two weeks. Stair climbing training and quadriceps training + standing hamstring curls with weight at ankle for lower limb concentric training progres
• Other Aerobic training Group
  Aerobic training as a control will be given to this group as well for approximately 60 minutes per session. Aerobic training exercise will be completed via a ergometer/stationary cycle; type will be continuous aerobic exercise and intensity of 60% of max HR (or peak VO2) in HF individuals.

Primary outcome measures

• Ventricle Functions [Time frame: 12 week]
• Aerobic Capacity [Time frame: 12 week]

Secondary outcome measures (9)

• Quality of life (Minnesota Living with Heart Failure Questionnaire) [Time frame: 12 week]
• Strength [Time frame: 12 week]
• Maximal strength of respiratory muscles [Time frame: 12 week]
• Forced Expiratory Volume in 1 second (FEV1) [Time frame: 12 week]
• Forced vital Capacity (FVC) [Time frame: 12 week]
• Peak Expiratory Flow (PEF) [Time frame: 12 week]
• Cardiac Risk Factors - Blood Pressure [Time frame: 12 week]
• Cardiac Risk Factors - Body mass index [Time frame: 12 week]
• Cardiac Risk Factors - Lipid profile [Time frame: 12 week]

Eligibility criteria

Inclusion criteria

• Diagnosis of Chronic HF and currently stable with optimal medical therapy
• Chronic Heart failure with ejection fraction > 30 %
• Patient able to safely perform lower limb exercise will be check by six- minute walk test (6 MWT)

Exclusion criteria

• Those Heart failure patient whose are in acute phase or planed for any immediate medical intervention
• Already participating in cardiac rehabilitation
• New York Heart Association (NYHA) Classification of HF class IV HF symptoms
• Co-existent other disease such as asthma/ COPD/interstitial lung disease.
• Symptomatic Second degree or third degree heart block.
• ECG with uncontrolled ventricular arrhythmia
• Limited Exercise ability due to neurologic or orthopedic impairments of the legs (will cross-check with 6 MWT)

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation

Randomized

Model

Parallel assignment

Masking

Double blind

Primary purpose

Other

Study locations

Pakistan · 2 centers

• Pakistan Railway Hospital — Rawalpindi
• Rawalpindi Institute of Cardiology — Rawalpindi

Identifiers

NCT: NCT06032780 · ISB/REC/PhD/01199 Iqbal Tariq

Primary sources (government registries)

• ClinicalTrials.gov (US NIH)

View this study on ClinicalTrials.gov ↗