Utility of CC7 Transfer in Stroke Subtypes
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Contralateral C7 root transfer for the treatment of spastic hemiparesis..
- Who it may be relevant to
- Registry conditions: Stroke, Ischemic, Stroke Hemorrhagic, Spastic Hemiparesis. Basic parameters: 18 years — 65 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Seventh Cervical Nerve Transfer for Spastic Arm Paresis: A Prospective Analysis of Efficacy in Ischemic vs. Hemorrhagic Stroke
Overview
The purpose of this study is to evaluate the limb functional improvement after contralateral C7 root transfer in stroke patients.
Detailed description
Spastic limb paresis after stroke is a cause of long-term disability and reduction is quality of life, with loss of hand dexterity being especially prohibitive. In the recovery phase after initial injury, neural reorganization occurs and has been observed in both ipsilateral and contralateral hemispheres. Previous studies have identified contralesional (opposite to the side of the injury), in other words, ipsilateral, activation in the recovery of paretic hand function. However, this pathway of recovery is limited due to sparse connections between the ipsilateral hemisphere and the affected arm/hand. By establishing an anatomic connection between the ipsilateral hemisphere and the paretic arm with contralateral nerve transfer, compensatory capacity of the ipsilateral hemisphere is facilitated. This cross neck C7-C7 root transfer is an established procedure for the treatment of brachial plexus injuries and recently, for the treatment of spastic arm paresis in those with cerebral injury.
Interventions
- Procedure Contralateral C7 root transfer for the treatment of spastic hemiparesis.
Performing surgery to transfer the C7 nerve to treat stroke patients experiencing spastic hemiparesis.
Primary outcome measures
- Change from baseline in arm function, as measured by the Fugl-Meyer upper-extremity scale. [Time frame: 12 months with visits at baseline and months 2, 4, 8, and 12 months after surgery.]
Eligibility criteria
Inclusion criteria
- History of ischemic or hemorrhagic stroke with resultant arm paresis that has ceased to improve within 1-5 years of rehabilitation.
- baseline Fugl-Meyer score below 33
Exclusion criteria
- pregnancy
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
United States · 1 center
- Dartmouth-Health — Lebanon
Identifiers
NCT: NCT06001736 · STUDY02000586