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Not yet recruiting NCT05987865

Neurofeedback Training for PD

No phase Interventional Parkinson Disease Healthy

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Neurofeedback training.
Who it may be relevant to
Registry conditions: Parkinson Disease, Healthy. Basic parameters: 18 years — 75 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Center list to be confirmed — check the primary protocol.
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

EEG- or STN LFP-based Neurofeedback Training for Improving Motor Functions in Parkinson's Disease

Overview

The goal of this clinical trial is to test neurofeedback training in both people with Parkinson's disease and healthy control. The main questions it aims to answer are: * To demonstrate that EEG based or STN LFP based neurofeedback can help patients with Parkinson's disease to volitionally modulate pathological brain activities measured non-invasively; * To evaluate the learning effect of the neurofeedback training with multiple training sessions Patient participants will be asked to receive the research intervention called neurofeedback training for maximal three separate sessions. During the intervention, the participants will also be asked to press a pinch meter as fast as possible in order to measure the reaction time, meanwhile, different type of brain signals will be recorded. . This will be a within-subject cross-over study contrasting the effect of the neurofeedback training and no training.

Interventions

  • Behavioral Neurofeedback training
    Features related to PD symptoms will be extracted from the brain recordings in real-time and used to drive a visual cursor on a computer screen placed in front of the participant, while the participant will be asked to try to control the cursor by regulating their brain signals.

Primary outcome measures

  • The feasibility of using EEG-based neurofeedback to help patients with Parkinson's disease to volitionally modulate pathological brain activities measured non-invasively. [Time frame: 10 days]
  • Learning effect of the neurofeedback training with multiple training sessions [Time frame: 10 days]
Secondary outcome measures (6)
  • The effect of EEG-based neurofeedback on motor performance quantified as reaction time in patients with Parkinson's disease [Time frame: 10 days]
  • The effect of EEG-based neurofeedback on motor performance quantified as peak movement velocity in patients with Parkinson's disease [Time frame: 10 days]
  • The effect of EEG-based neurofeedback on parkinsonian tremor [Time frame: 10 days]
  • The effect of EEG-based neurofeedback on motor Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) score [Time frame: 10 days]
  • The effect of EEG-based neurofeedback on motor performance quantified as reaction time in healthy age-matched control [Time frame: 10 days]
  • The peak movement velocity during the cued motor task will be measured, and compared between training and no-training conditions in healthy age-matched control group. [Time frame: 10 days]

Eligibility criteria

Inclusion criteria

  • Participants with symptomatic Parkinson's disease or age-matched healthy control
  • Adequate understanding of verbal explanation or written information given in English
  • Able and willing to give informed consent.
  • Normal or corrected-to-normal vision

Exclusion criteria

  • Lack of capacity to consent (judged by the researcher taking consent as not having sufficient mental capacity to understand the study and its requirements)

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
N/A
Model
Single group
Masking
Open label
Primary purpose
Basic science

Study locations

Center list to be confirmed — check the primary protocol.

Identifiers

NCT: NCT05987865 · 249990

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗