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Recruiting NCT05985668

Towards Improved Diagnostics for Suspected Platelet Function Disorders

— Observational Platelet Function Disorder Platelet Disorder Thrombocytopathy

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
This is an observational study: the protocol does not assign a study treatment.
Who it may be relevant to
Registry conditions: Platelet Function Disorder, Platelet Disorder, Thrombocytopathy. Basic parameters: from 12 months · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Sweden
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Overview

This study aims to improve platelet function testing during bleeding investigations. To this end, the study will evaluate the diagnostic accuracy of novel platelet function tests in patients with confirmed or suspected platelet function disorders. Study participants will be recruited from patients that are referred to or treated at the Coagulation Unit, Karolinska University Hospital, and Pediatric Coagulation Unit, Astrid Lingren Children's Hospital.

Primary outcome measures

  • Platelet-thrombus formation on collagen surface [Time frame: At study inclusion]

Eligibility criteria

Inclusion Criteria, known defects:

  • Known platelet function disorder under follow-up at Karolinska University Hospital (genetic or functional assay)
  • High likelihood of platelet function disorder (aberrant screening test with inheritance)
  • Family investigation for platelet disorder

Exclusion Criteria, known defects::

  • Antiplatelet or anticoagulant drugs
  • vWF:GPIb below 0.40 IU/mL
  • Hematocrit below 0.35 or above 0.50
  • Other coagulation disorder

Inclusion Criteria, suspected platelet function disorder:

  • Bleeding investigation at Karolinska University Hospital

Exclusion Criteria, suspected platelet function disorder::

  • Antiplatelet or anticoagulant drugs
  • vWF:GPIb below 0.40 IU/mL
  • Hematocrit below 0.35 or above 0.50
  • Other coagulation disorder

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Observational model
Cohort

Study locations

Sweden · 1 center
  • Karolinska University Hospital — Stockholm

Identifiers

NCT: NCT05985668 · K-2023-0991

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗