Impact of Emotional Reactivity on Dysfunctional Decision-Making in NSSI Adolescents
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Nonsuicidal Self Injury, Prediction Errors. Basic parameters: 15 years — 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Effects of Emotional Reactivity on Decision-Making in Adolescents With Nonsuicidal Self-Injury
Overview
Nonsuicidal self-injury (NSSI) is defined as direct, intentional physical injury without suicidal intention. Studies revealed that dysfunctional interpersonal relationships and reward-related decision-making may play crucial roles in this maladaptive behavior, especially in adolescents. These interpersonal decision contexts are characterized by constant updating of expectations of rewards and the actual received rewards as well as the associated emotional reactions. These processes have recently been computationally formalized as prediction errors (PE), specifically reward PEs, valence PEs, and arousal PEs (Heffner et al., 2021; Nat Hum Behav). In the current study, the investigators aim to investigate whether these PEs make discernible contributions to social decisions in the context of unfair experiences among adolescents with NSSI and matched healthy control adolescents (HC). Specifically the investigators hypothesized that: 1) reward and emotional PEs show significant predictions of punishment decisions in both groups, 2) however, compared to HC adolescents, the NSSI group will exhibit selective dysfunctions in emotional but not reward PEs leading to punish a norm proposer who provided unfair offers.
Primary outcome measures
- Reward prediction errors (PEs) [Time frame: About 20 minutes]
- Valence prediction errors (PEs) [Time frame: About 20 minutes]
- Arousal prediction errors (PEs) [Time frame: About 20 minutes]
- The prediction of PEs of punishment decisions [Time frame: About 20 minutes]
Eligibility criteria
Inclusion criteria
- 15-18 years
- right-handed
- normal or corrected normal visual acuity
- meet the proposed DSM-5 frequency criteria (e.g., ≥5 days of NSSI behaviors in the past year)
Exclusion criteria
- diagnosis of borderline personality disorder, major depressive disorder, other
- psychiatric disorders, etc.
- high suicidal risk
- recent use of medications that can affect neural activity
- have received or are receiving Dialectical Behavior Therapy (DBT) other treatment for emotional problems within the past 6 months
- have a contraindication to MRI scanning (e.g., metal implants, claustrophobia or other conditions that make them inappropriate for MRI scanning)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Case-control
Study locations
China · 1 center
- Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, Univers — Chengdu
Identifiers
NCT: NCT05981612 · BAM_lab_NSSI_04