Localized Analysis of Normalized Distance From Scalp to Cortex and Personalized Evaluation (LANDSCAPE)
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Transcranial Magnetic Stimulation.
- Who it may be relevant to
- Registry conditions: Aging, Dementia Alzheimers, Parkinson Disease, Dementia Frontotemporal. Basic parameters: 60 years — 95 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Hong Kong
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Localized Analysis of Normalized Distance From Scalp to Cortex and Personalized Evaluation (LANDSCAPE): A Project of MRI-informed Computational Head Model
Overview
Scalp to cortex distance (SCD), as a key technological parameter of brain stimulation, has been highlighted in the guidelines of non-invasive brain stimulation. However, in the context of age-related brain changes, the region-specific SCD and its impact on stimulation-induced electric field in different types of neurodegenerative diseases remain unclear.
Detailed description
Objective: This study aimed to investigate the region-specific SCD and its relationship with morphometric features and cognitive function in age- and disease-specific populations. Methods: The SCD and cortical thickness (CT) of left primary motor cortex (M1) and dorsolateral prefrontal cortex (DLPFC) were measured in cognitively normal adults and dementia patients. CT-adjusted SCD was used to control the influence of CT on SCD. Head model was developed to simulate the impact of SCD on the electric field induced by transcranial electrical stimulation.
Interventions
- Device Transcranial Magnetic Stimulation
One time for each day, lasting for three weeks.
Primary outcome measures
- Scalp-to-cortex distance will be measured using geometric brain model [Time frame: Baseline]
Eligibility criteria
Inclusion criteria
- Right-handed as assessed by the Edinburgh Inventory
- Able to attend TMS interventions
- Consent
- Independent in daily life activities
Exclusion criteria
- Uncorrected visual or auditive deficits not allowing the realization of the test
- Evolutive disease (such as cancer)
- Neurological or psychiatric antecedent
- Counter-indication to MRI
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-control
Study locations
Hong Kong · 1 center
- Tai Po Hospital — Hong Kong
Identifiers
NCT: NCT05967390 · 2018.077 · 2018.077