Registry of Multicenter Brain-Heart Comorbidity in China
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Multi-disciplinary assessment.
- Who it may be relevant to
- Registry conditions: Ischemic Heart Disease, Cardiac Arrest, Atrial Fibrillation, Heart Failure. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
This study is a multi-center, prospective, registry study. This research was supported by the National Key Research and Development Program. To establish a domestic multi-center, large-scale "brain-heart comorbidity" dynamic database platform including clinical, sample database, image and other multi-dimensional information requirements, through the construction of a multi-center intelligent scientific research integration platform based on artificial intelligence. Any of newly diagnosed cardiovascular related diseases were identified via ICD-10-CM codes: I21, I22, I24 (Ischaemic heart diseases) \[i.e., ACS\], I46 (cardiac arrest), I48 (Atrial fibrillation/flutter), I50 (Heart failure), I71 (Aortic disease), I60 (subarachnoid hemorrhage), I61 (intracerebral hemorrhage), I63 (Cerebral infarction), I65 (Occlusion and stenosis of precerebral arteries), I66 (Occlusion and stenosis of cerebral arteries), I67.1 (cerebral aneurysm), I67.5 (moyamoya diseases), Q28.2 (Arteriovenous malformation of cerebral vessels). The data is stored on the brain-heart comorbidity warehouse via a physical server at the institution's data centre or a virtual hosted appliance. The brain-heart comorbidity platform comprises of a series of these appliances connected into a multicenter network. This network can broadcast queries to each appliance. Results are subsequently collected and aggregated. Once the data is sent to the network, it is mapped to a standard and controlled set of clinical terminologies and undergoes a data quality assessment including 'data cleaning' that rejects records which do not meet the brain-heart comorbidity quality standards. The brain-heart comorbidity warehouse performs internal and extensive data quality assessment with every refresh based on conformance, completeness, and plausibility (http://10.100.101.65:30080/login).
Interventions
- Other Multi-disciplinary assessment
Multi-disciplinary assessment
Primary outcome measures
- Rate of Participants with Composite of All-Cause Mortality and Cardiovascular Outcomes [Time frame: At discharge/30 days]
- All-Cause Mortality [Time frame: At discharge/30 days]
- Rate of Participants with Composite of Cardiovascular Outcomes [Time frame: At discharge/30 days]
Eligibility criteria
Inclusion criteria
- age > 18 years old
- Any of newly diagnosed cardiovascular-related diseases were identified via ICD-10-CM codes: I21, I22, I24 (Ischaemic heart diseases) \[i.e., ACS\], I46 (cardiac arrest), I48 (Atrial fibrillation/flutter), I50 (Heart failure), I71 (Aortic disease), I60 (subarachnoid hemorrhage), I61 (intracerebral hemorrhage), I63 (Cerebral infarction), I65 (Occlusion and stenosis of precerebral arteries), I66 (Occlusion and stenosis of cerebral arteries), I67.1 (cerebral aneurysm), I67.5 (moyamoya diseases), Q28.2 (Arteriovenous malformation of cerebral vessels).
Exclusion criteria
·refuse to participate in the registry
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Cohort
Study locations
China · 14 centers
- Beijing Tiantan Hospital, Capital Medical University — Beijing
- Beijing Anzhen Hospital, Capital Medical University — Beijing
- Beijing Chaoyang Hospital, Capital Medical University — Beijing
- Chinese People's Liberation Army (PLA) General Hospital — Beijing
- Peking University First Hospital — Beijing
- Xuanwu Hospital, Capital Medical University — Beijing
- The First Affiliated Hospital of Fujian Medical University — Fuzhou
- The First Affiliated Hospital of Xiamen University — Xiamen
- … and 6 more centers
Publications
- Lu J, Lin F, Weng J, Lyu J, Zhang L, Song W, Zhu B, Ma M, Xu H, Xue J, Liu M, Zhang Y, Chen Y, Li R, Wang K, Liu H, Chen X, Zhao J, Liu MJ. Serum Lipid Profiles and the Burden of Polyvascular Atherosclerosis: A Cross-Sectional CTA-Based Study in a Chinese Cohort. J Stroke Cerebrovasc Dis. 2026 Jul 30:108715. doi: 10.1016/j.jstrokecerebrovasdis.2026.108715. Online ahead of print. PMID 42532457
Identifiers
NCT: NCT05961748 · KY2022-221-02