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Recruiting NCT05960474

Coronary Microvascular Disease (CMD) Registry

— Observational Coronary Microvascular Dysfunction

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Outcomes for Patients with CMD.
Who it may be relevant to
Registry conditions: Coronary Microvascular Dysfunction. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United States
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Overview

The purpose of this project is to provide appropriate administrative and technical supports for the warehousing and use of a database of patients with coronary microvascular disease (CMD). This protocol will outline the process for identification and capture of data, storage, as well as data use and sharing internally and externally for research purposes.

Interventions

  • Other Outcomes for Patients with CMD
    Our objective is to perform a retrospective/prospective descriptive study on the short term to longterm (up to 5 years of follow-up) outcomes of patients with coronary microvascular disease diagnosis invasively

Primary outcome measures

  • Establish a Registry of CMD patients [Time frame: 10 years]

Eligibility criteria

Inclusion criteria

  • Those with Coronary Microvascular Disease

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Study design

Observational model
Other

Study locations

United States · 3 centers
  • Medstar Washington Hospital Center — Washington D.C.
  • Memorial Regional Hospital — Hollywood
  • MedStar Southern Maryland — Clinton

Publications

  • Hill AP, Wallace RL, Chaturvedi A, Frisancho FT, Cellamare M, Sawant V, Ozturk S, Cermak V, Zhang C, Waksman R, Hashim HD, Case BC. Comparative Visual Analysis of Coronary Slow Flow and Myocardial Blush Grade in Relation to Invasive Testing for Coronary Microvascular Dysfunction. Catheter Cardiovasc Interv. 2025 Dec;106(7):3953-3958. doi: 10.1002/ccd.70246. Epub 2025 Oct 23. PMID 41128690
  • Al Qaraghuli A, Chitturi KR, Kumar S, Cellamare M, Ozturk S, Sawant V, Zhang C, Verma BR, Galo J, Chaturvedi A, Ben-Dor I, Satler L, Rogers T, Waksman R, Hashim H, Case BC. Exploring the impact of age on microvascular function: Insights from the Coronary Microvascular Disease Registry. Int J Cardiol. 2026 Jan 1;442:133858. doi: 10.1016/j.ijcard.2025.133858. Epub 2025 Sep 2. PMID 40907829
  • Chitturi KR, Kumar S, Verma BR, Abusnina W, Cellamare M, Merdler I, Ozturk ST, Cermak V, Sawant V, Ben-Dor I, Waksman R, Hashim HD, Case BC. The incremental diagnostic value of microvascular resistance reserve in the assessment of coronary microvascular dysfunction. Cardiovasc Revasc Med. 2025 Jul;76:35-39. doi: 10.1016/j.carrev.2025.06.009. Epub 2025 Jun 18. PMID 40562606
  • Abusnina W, Merdler I, Cellamare M, Chitturi KR, Chaturvedi A, Feuerstein IM, Zhang C, Ozturk ST, Deksissa T, Sawant V, Lopez K, Lupu L, Haberman D, Ben-Dor I, Satler LF, Waksman R, Hashim HD, Case BC. Epicardial Fat Tissue: A Potential Marker for Coronary Microvascular Dysfunction. J Am Heart Assoc. 2025 Feb 4;14(3):e038484. doi: 10.1161/JAHA.124.038484. Epub 2025 Feb 3. PMID 39895522
  • Chitturi KR, Kumar S, Frisancho FT, Rahman S, Verma BR, Cellamare M, Merdler I, Ozturk ST, Cermak V, Sawant V, Zhang C, Ben-Dor I, Waksman R, Hashim HD, Case BC. The Prevalence of Coronary Microvascular Dysfunction in Patients With Type 2 Diabetes Mellitus. Catheter Cardiovasc Interv. 2025 Apr;105(5):1120-1123. doi: 10.1002/ccd.31429. Epub 2025 Jan 29. PMID 39888248
  • Chitturi KR, Kumar S, Hill AP, Lorente-Ros M, Cellamare M, Merdler I, Abusnina W, Haberman D, Lupu L, Chaturvedi A, Ozturk ST, Cermak V, Sawant V, Zhang C, Ben-Dor I, Tsimploulis A, Waksman R, Hashim HD, Case BC. Prevalence of Arrhythmias in Patients With Coronary Microvascular Dysfunction. Catheter Cardiovasc Interv. 2025 Feb;105(2):483-490. doi: 10.1002/ccd.31324. Epub 2024 Dec 11. PMID 39660783
  • Merdler I, Chitturi KR, Chaturvedi A, Li J, Cellamare M, Ozturk ST, Sawant V, Ben-Dor I, Waksman R, Case BC, Hashim HD. Coronary microvascular dysfunction and inflammation: Insights from the Coronary Microvascular Disease Registry. Cardiovasc Revasc Med. 2024 Dec;69:30-34. doi: 10.1016/j.carrev.2024.05.020. Epub 2024 May 11. PMID 38789342
  • Merdler I, Chitturi KR, Chaturvedi A, Rahman S, Cellamare M, Ozturk ST, Sawant V, Ben-Dor I, Waksman R, Hashim HD, Case BC. Exploring the interplay between coronary microvascular dysfunction and mental health. Cardiovasc Revasc Med. 2024 Dec;69:25-29. doi: 10.1016/j.carrev.2024.05.019. Epub 2024 May 11. PMID 38789341

Identifiers

NCT: NCT05960474 · CMDR

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗