Influence of Autonomy on Motor Learning in People With Parkinson's Disease
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Autonomy supported learning, Practice with predetermined feedback.
- Who it may be relevant to
- Registry conditions: Parkinson Disease. Basic parameters: from 20 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Taiwan
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The goal of this clinical trial is to explore the benefits of autonomy supported learning in patients with Parkinson's disease. The main questions to answer are: * Whether autonomy supported learning can benefit motor learning in PD patients * Whether autonomy supported learning can enhance intrinsic motivation and/ or information processing of PD patients in learning a new task. * Whether autonomy supported learning can facilitate cortical excitability change after practicing a new task. Participants will be recruited into two groups (Self-control group, SC; and yoked group, YK) to learn a finger-pressing trajectory matching task * Participants in SC group will have choice over feedback schedule during trial practice * Participants in YK group will receive feedback with no-choice during trial practice Researchers will compare the retention test performance to see if autonomy supported learning will lead to better learning effect.
Detailed description
Autonomy is the sense of learner to actively participate in determining their own behaviour. The present study aims to investigate whether an autonomy supported practice (with self-controlled feedback) would benefit adults with Parkinson's disease (PD), along with increased intrinsic motivation, information processing and cortical excitability. Two groups of healthy adults and two groups of PD patients will be recruited to learn a finger-pressing trajectory matching task. Participants will be allocated in either a self-control group (choice over feedback schedule), or a yoked group (receive feedback with no-choice). Learning will be assessed on the second day and one week later, along with an error estimation of learners' own performance to represent their information processing ability. Cortical excitability and inhibition will be assessed via transcranial magnetic stimulation as indicators of cortical plasticity. Questionnaire regarding motivation will be assessed before and after practice trials. Study hypothesized that individual with PD would benefit from autonomy supported learning, with better performance, enhanced motivation and information processing, associates with change of cortical excitability
Interventions
- Behavioral Autonomy supported learning
The ability of learners to participate in determining their own behaviour, which is the feedback schedule regarding their practice performance in this study. - Behavioral Practice with predetermined feedback
Learners practice the motor task, while the feedback is provided according to their counterpartner
Primary outcome measures
- Performance accuracy [Time frame: up to day 7]
Secondary outcome measures (3)
- Intrinsic Motivation Inventory [Time frame: day 1, day 2, day 7]
- Error Estimation [Time frame: day 2, day 7]
- Cortical excitability changes [Time frame: Baseline, day 2, day 7]
Eligibility criteria
Inclusion criteria
- age above 20-years-old
- able to follow instructions to perform the tasks (Montreal Cognitive Assessment ≥ 24)
- no surgery and injury in upper extremities in recent 6 months
Exclusion criteria
- other neurological disorders in addition to Parkinson's disease
- Parkinson's disease dementia
- symptom of severe tremor in upper extremities (score ≥ 3 in Question 15 to 18 of UPDRS-III)
- deep brain stimulation or pacemaker implanted
- medical history of seizure
- a blood-relative with history of epilepsy
- unstable medical conditions
- pregnancy
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Non-randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
Taiwan · 1 center
- National Taiwan University Hospital — Taipei
Publications
- Carter MJ, Ste-Marie DM. Not all choices are created equal: Task-relevant choices enhance motor learning compared to task-irrelevant choices. Psychon Bull Rev. 2017 Dec;24(6):1879-1888. doi: 10.3758/s13423-017-1250-7. PMID 28224481
- Chiviacowsky S, Wulf G, Lewthwaite R, Campos T. Motor learning benefits of self-controlled practice in persons with Parkinson's disease. Gait Posture. 2012 Apr;35(4):601-5. doi: 10.1016/j.gaitpost.2011.12.003. Epub 2011 Dec 30. PMID 22209649
- Lim DJ, Tai CH, Chen SY, Huang CY, Lee YY. Self-Controlled Feedback on Motor Learning and Neuroplastic Changes in People With Parkinson Disease. J Neurol Phys Ther. 2026 Jul 1;50(3):166-173. doi: 10.1097/NPT.0000000000000553. Epub 2026 Apr 17. PMID 41992310
Identifiers
NCT: NCT05960331 · 202304047RINC