Consistency of Carotid Doppler Blood Flow and Thermodilution Technique
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: passive leg raising, Dobutamine.
- Who it may be relevant to
- Registry conditions: Cardiac Surgery. Basic parameters: 18 years — 80 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
The Consistency of Tracking Changes of Cardiac Output by Carotid Doppler Blood Flow and Thermodilution Technique in Cardiac Surgery Patients
Overview
Currently, the gold standard method to estimate CO is the thermodilution technique, pulmonary artery catheter (PAC) and PiCCO system included, however, the invasiveness and complexity of the thermodilution technique have limited their usefulness in many clinical scenarios. By measuring the carotid blood flow, continuous carotid doppler technique has been reported to noninvasively estimate cardiac output (CO) and other parameters related to cardiac contractility and fluid status in various cardiovascular disorders. However, to the best of our knowledge, few study has been reported to evaluate the consistency of this technique in cardiac surgery patients. The aim of this study is to evaluate the tracking ability of CO changes measured by continuous carotid doppler technique in cardiac surgery patients, use the thermodilution technique as the referenced.
Interventions
- Behavioral passive leg raising
transfer a patient from semi-recumbent position to supine position with a 45° leg lifting - Drug Dobutamine
infusion dobutamine
Primary outcome measures
- cardiac output by thermodilution method [Time frame: 5 minutes after the patients was sedated]
- cardiac output by continuous carotid doppler blood flow [Time frame: 5minutes after the patients was sedated]
- cardiac output by thermodilution method [Time frame: 2 minutes after passive leg raising]
- cardiac output by continuous carotid doppler blood flow [Time frame: 2 minutes after passive leg raising]
- cardiac output by thermodilution method [Time frame: 15 minutes after termination of passive leg raising]
- cardiac output by continuous carotid doppler blood flow [Time frame: 15 minutes after termination of passive leg raising]
- cardiac output by thermodilution method [Time frame: 30 minutes after dobutamine infusion]
- cardiac output by continuous carotid doppler blood flow [Time frame: 30 minutes after dobutamine infusion]
Eligibility criteria
Inclusion criteria
- adult cardiac surgery patients
- with thermodilution technique monitoring
- mechanical ventilation
Exclusion criteria
- life threatening arrhythmia
- severe valve regurgitation
- left ventricular ejection fraction less than 30%
- patients with mechanical circulatory support
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Diagnostic
Study locations
China · 1 center
- Zhongshan hospital Fudan University — Shanghai
Publications
- Hao GW, Huang DL, Ma GG, Su Y, Hou JY, Zhang YJ, Liu WJ, Lu ZH, Luo Z, Tu GW. Ability of the continuous carotid Doppler patch to track directional changes in cardiac output in cardiac surgery patients. Eur J Med Res. 2026 Feb 24. doi: 10.1186/s40001-026-04034-3. Online ahead of print. PMID 41736158
Identifiers
NCT: NCT05944146 · Cracard