Examining the Role of Female Endogenous Sex Hormones in Eccentric Exercise
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Eccentric leg extension.
- Who it may be relevant to
- Registry conditions: Inflammatory Response. Basic parameters: 18 years — 35 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The fluctuating concentrations of female sex hormones, namely estrogen and progesterone may have an effect on the ability of the tissue to withstand challenging exercise conditions, such as eccentric exercise. These sex hormones have also been purported to influence the perceived difficulty of exercise. This study aims to uncover how the different estrogen and progesterone concentrations present throughout the menstrual cycle effect perceived readiness to perform, perceptions of difficulty, and different recovery metrics.
Detailed description
Although nearly half of the population is female, less than 10% of research resources are allocated to understanding how their dynamic physiology impacts athletic readiness, performance, and recovery. The fluctuating concentrations of female sex hormones, namely estrogen and progesterone may have an effect on the ability of the tissue to withstand challenging exercise conditions, such as eccentric exercise. This study aims to uncover how the different estrogen and progesterone concentrations present throughout the menstrual cycle effect perceived readiness to perform, perceptions of difficulty, and the inflammatory environment and quantification of muscle damage.
Interventions
- Behavioral Eccentric leg extension
Participants will complete a 10 x 10 eccentric leg extension on a Cybex Norm dynamometer. Upon arrival, participants will be asked their perceived readiness to perform on a 11 point numeric rating scale. Before the running protocol a baseline blood sample will be collected, as well as passive and active delayed onset muscle soreness (DOMS), a countermovement jump. Half way through each set (i.e., after the 5th repetition) participants will be asked to rank their level of difficulty on a 11 point
Primary outcome measures
- Preparedness to perform [Time frame: Pre exercise]
- Rating of difficulty [Time frame: 30 minutes]
- Inflammatory markers [Time frame: Change over time (pre/post, 24 hour, 48 hour)]
- Counter movement jump height [Time frame: Change over time (pre/post, 24 hour, 48 hour)]
- Passive Delayed Onset Muscle Soreness (DOMS) [Time frame: Change over time (pre/post, 24 hour, 48 hour)]
- Active Delayed Onset Muscle Soreness (DOMS) [Time frame: Change over time (pre/post, 24 hour, 48 hour)]
Eligibility criteria
Inclusion criteria
- 18-35 years of age
- BMI of 18.5-29.9 as a BMI below or above these cut points results in highly varied menstrual cycle lengths \[15\]
- Not taking contraception or other types of medication that could influence reproductive status
- Regular menstruation
- Non-pregnant
- Medically free from chronic diseases
- Novel to downhill running
- Weight greater than or equal to 110 lbs
- Not taking exogenous hormones
- Not suffering from known gynecological disease (i.e., PCOS, endometriosis, etc.) that may influence menstrual cycle regularity
Exclusion criteria
- Amenorrhea or oligomenorrhea
- Perimenopausal or menopausal
- Recreational or professional trail or downhill runner
- On a form of contraception
- Cardiac disability
- Pacemaker
- Arterial disease
- Uncontrolled hemorrhage
- Blood clots
- Pregnant or trying to become pregnant
- Cancerous lesions
- Sensory or mental impairment
- Unstable fractures
- Weight less than 110 lbs
- Suffering from gynecological disease (i.e., PCOS, endometriosis, etc.) that may influence menstrual cycle regularity
- Taking exogenous hormones
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Health services research
Study locations
United States · 1 center
- Clinical Exercise Research Center — Los Angeles
Identifiers
NCT: NCT05934708 · HS-23-00363