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Recruiting NCT05924178

Effects of Preoperative Rehabilitation on Tendon Healing, Bone Mineral Density, and Cartilage After ACLR and Patellar Dislocation

No phase Interventional Anterior Cruciate Ligament Rupture

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: exercise rehablitation, routine treatment.
Who it may be relevant to
Registry conditions: Anterior Cruciate Ligament Rupture. Basic parameters: 18 years — 45 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
China
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

A Study on the Effect of Exercise Rehabilitation on Bone Mineral Density, Reconstruction Ligament Tendon Bone Healing and Cartilage After ACL Rupture and Patellar Dislocation

Overview

To explore the effect of preoperative exercise rehabilitation on bone mineral density, tendon bone healing, change of cartilage, and gait feature in patients with anterior cruciate ligament rupture.

Detailed description

Anterior Cruciate Ligament (ACL) injury is one of the most common sports injuries. It is a serious knee injury. The fracture of ACL can cause functional instability of knee joint, damage of meniscus and articular cartilage, and even induce knee osteoarthritis and other diseases. It has great influence on knee joint and even lower limb function of patients. Arthroscopic ACL reconstruction has become the first choice in clinical treatment of ACL fracture.

ACL fracture can cause local knee joint osteoporosis, and reconstruction surgery can also affect tendon bone healing, bone canal enlargement, rehabilitation period, gait, articular cartilage degradation, etc.

This study intends to conduct preoperative rehabilitation intervention for young people with anterior fork rupture, and explore the effects of exercise rehabilitation on knee bone mineral density, muscle strength, proprioceptive ability and other aspects after ACL rupture, as well as the effects of knee bone mineral density, tendon bone healing, bone tunnel aperture, motor function, gait characteristics and cartilage degradation after reconstruction.

Interventions

  • Behavioral exercise rehablitation
    Preoperative exercise rehabilitation in experimental group was performed.
  • Behavioral routine treatment
    The control group receives conventional treatment preoperative.

Primary outcome measures

  • Grade of tendon bone healing [Time frame: At 6 monthes post operation.]
  • Grade of tendon bone healing [Time frame: At 1 year post operation.]
  • balanced capacity [Time frame: At preoperative.]
  • balanced capacity [Time frame: At 6 monthes post operation.]
  • balanced capacity [Time frame: At 1 year post operation.]
  • knee T1 rho value [Time frame: At 6 months post operation.]
  • knee T1 rho value [Time frame: At 1 year post operation.]
  • knee T2 value [Time frame: At 6 months post operation.]
  • knee T2 value [Time frame: At 1 year post operation.]
  • knee extension angles [Time frame: At 6 months post operation.]
Secondary outcome measures (7)
  • The HU value of CT [Time frame: at pre-operation]
  • Thigh Circumference [Time frame: At 2 years post operation.]
  • Thigh Circumference [Time frame: At 1 year post operation.]
  • Thigh Circumference [Time frame: At 6 monthes post operation.]
  • Thigh Circumference [Time frame: At pre-operation.]
  • Single-Leg Hop [Time frame: At 1 year post operation.]
  • Single-Leg Hop [Time frame: At 2 years post operation.]

Eligibility criteria

Inclusion criteria

  • Age 18\~40 years old, diagnosed ACL rupture or Patellar Dislocation by MRI;
  • The first unilateral ligamenta reconstruction at our hospital;

Exclusion criteria

  • Be older than 40 years, or less than 18 years old
  • Severe injury to other knee ligaments
  • History of knee trauma

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Single blind
Primary purpose
Treatment

Study locations

China · 1 center
  • Peking University Third Hospital — Beijing

Publications

  • Wu Y, Yan W, Dai W, Ren S, Ao Y, Gong X. The effect of preoperative rehabilitation exercises on postoperative bone mineral density, tendon-bone healing, and physical function after anterior cruciate ligament reconstruction: a multi-center randomized controlled clinical trial. BMC Sports Sci Med Rehabil. 2026 Jun 30. doi: 10.1186/s13102-026-01841-3. Online ahead of print. PMID 42374474

Identifiers

NCT: NCT05924178 · M2022837

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗