Flexible Reaching Control in Parkinson Disease
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Reaching movements, Disease Assessment.
- Who it may be relevant to
- Registry conditions: Parkinson Disease. Basic parameters: 18 years — 99 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Belgium
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Behavioural Study of Reaching Control in Healthy Volunteers and Volunteers With Parkinson Disease in Dynamical Context
Overview
Current research and theories have highlighted that the parameters linked to movement planning, e.g. the decision to select a movement goal, and adaptation, e.g. the ability to update control dependent on a novel dynamical context, are update quickly and within an ongoing movement in the general population. In parallel, it has been suggested that the evaluation of movement costs is a function of the basal ganglia, and it is impaired in Parkinson disease (PD). Here the investigators want to test whether these mechanisms also alter the ability of patients to update control during an ongoing action. A positive result would confirm that movement-related costs and dynamical representations depend on the integrity of the basal ganglia, in contrast a negative result would indicate that the deficit in PD is more specifically related to movement initiation, which would invite one to reconsider the cause of bradykinesia in this population.
Interventions
- Other Reaching movements
Participants will be instructed to perform reaching movements by moving the handle of a robotic arm mounted with a virtual reality display. - Other Disease Assessment
Disease stage assessed by trained professionals
Primary outcome measures
- Kinematics [Time frame: Measured during the entire experiment (an average of 4.5 years)]
- Surface Electromyogram [Time frame: Measured during the entire experiment (an average of 4.5 years)]
- Applied forces [Time frame: Measured during the entire experiment (an average of 4.5 years)]
Eligibility criteria
Inclusion criteria
- Ability to perform the task (assessed during the experiment)
Exclusion criteria
- Inability to perform the task (motor) or to understand the task requirements (cognitive)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-control
Study locations
Belgium · 1 center
- Université catholique de Louvain — Louvain-la-Neuve
Identifiers
NCT: NCT05908266 · REACH-PD