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Recruiting NCT05893524

Uppsala-Dalarna Dementia and Gait Project

— Observational Dementia Dementia, Mixed Dementia Senile Dementia of Alzheimer Type

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Timed Up-and-Go (TUG single-task), Timed Up-and-Go dual-task (TUGdt), Clinical functional assessment.
Who it may be relevant to
Registry conditions: Dementia, Dementia, Mixed, Dementia Senile, Dementia of Alzheimer Type. Basic parameters: 37 years — 94 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Sweden
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Overview

UDDGait™ is a multidisciplinary research project with the overreaching goal of providing an aid for early identification of cognitive impairment and risk of dementia development, thereby providing a basis for adequate symptom relieving and health promoting interventions. A new concept is investigated for this purpose: a "dual-task-test", which implies the combination of a well-established mobility test (Timed Up-and-Go, TUG) with a simultaneous verbal task (i.e. TUG dual-task, TUGdt). This type of test has been judged as a potential aid for early identification of dementia disease. More research is needed to further examine the test's validity, reliability and predictive capacity. The overall aim is to investigate if TUGdt is useful as an aid for prediction of dementia disease. To ensure the results, the aim is also to evaluate the test's measurement properties and to generate normative reference values of healthy control persons.

Interventions

  • Diagnostic test Timed Up-and-Go (TUG single-task)
    The TUG test is a well-established clinical test of one mobility sequence: rising from an armchair, walking straight ahead, passing a line marked on the floor, turning around, walking back, and sitting down again.
  • Diagnostic test Timed Up-and-Go dual-task (TUGdt)
    Two dual-task tests including TUG (TUGdt) were carried out: TUGdt naming animals and TUGdt months backwards. The outcomes registered were: time scores for TUG single-task and both TUGdt tests, TUGdt costs (relative time difference between TUG single-task and TUGdt), number of different animals named, number of months recited in correct order, number of animals per 10 s, and number of months per 10 s.
  • Diagnostic test Clinical functional assessment
    The diagnostic procedure was part of the clinical routine for patients undergoing memory assessment and involved a geriatrician's careful evaluation of the patient's history and cognitive testing including Mini-Mental State Examination (MMSE), Clock Drawing Test, Verbal Fluency Test, and Trail Making Test A and B. In addition, all participants carried out short versions of the Geriatric Depression Scale and the General Motor Function Assessment Scale, as well as static balance according to the B

Primary outcome measures

  • Conversion to dementia [Time frame: Upp to 10 years]
Secondary outcome measures (1)
  • Level of cognitive functioning [Time frame: Upp to 10 years]

Eligibility criteria

Inclusion criteria

  • Patients undergoing memory assessment at at Uppsala University Hospital, Sweden
  • Patients undergoing memory assessment at at Falu Hospital, Sweden
  • Cognitively unimpaired individuals with a Mini Mental State Examination (MMSE) score of > 26

Exclusion criteria

  • Inability to walk three meters back and forth
  • Inability to rise from a sitting position
  • Indoor use of a walking aid
  • Current or recent hospitalization (within the last 2 weeks)
  • Need of an interpreter to communicate in Swedish

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Observational model
Cohort

Study locations

Sweden · 2 centers
  • Dalarna University — Falun
  • Uppsala University — Uppsala

Publications

  • Ahman HB, Giedraitis V, Cedervall Y, Lennhed B, Berglund L, McKee K, Kilander L, Rosendahl E, Ingelsson M, Aberg AC. Dual-Task Performance and Neurodegeneration: Correlations Between Timed Up-and-Go Dual-Task Test Outcomes and Alzheimer's Disease Cerebrospinal Fluid Biomarkers. J Alzheimers Dis. 2019;71(s1):S75-S83. doi: 10.3233/JAD-181265. PMID 31104024
  • Cedervall Y, Stenberg AM, Ahman HB, Giedraitis V, Tinmark F, Berglund L, Halvorsen K, Ingelsson M, Rosendahl E, Aberg AC. Timed Up-and-Go Dual-Task Testing in the Assessment of Cognitive Function: A Mixed Methods Observational Study for Development of the UDDGait Protocol. Int J Environ Res Public Health. 2020 Mar 5;17(5):1715. doi: 10.3390/ijerph17051715. PMID 32150995
  • Ahman HB, Cedervall Y, Kilander L, Giedraitis V, Berglund L, McKee KJ, Rosendahl E, Ingelsson M, Aberg AC. Dual-task tests discriminate between dementia, mild cognitive impairment, subjective cognitive impairment, and healthy controls - a cross-sectional cohort study. BMC Geriatr. 2020 Jul 29;20(1):258. doi: 10.1186/s12877-020-01645-1. PMID 32727472
  • B Ahman H, Berglund L, Cedervall Y, Kilander L, Giedraitis V, J McKee K, Ingelsson M, Rosendahl E, Aberg AC. Dual-Task Tests Predict Conversion to Dementia-A Prospective Memory-Clinic-Based Cohort Study. Int J Environ Res Public Health. 2020 Nov 3;17(21):8129. doi: 10.3390/ijerph17218129. PMID 33153203
  • Lofgren N, Giedraitis V, Halvorsen K, Rosendahl E, Aberg AC. The Timed Up and Go dual-task test's cognitive and motor outcomes show promising test-retest reliability in older adults with perceived memory impairment. Front Aging. 2026 Jan 8;6:1715756. doi: 10.3389/fragi.2025.1715756. eCollection 2025. PMID 41585362
  • Lofgren N, Berglund L, Giedraitis V, Rosendahl E, Aberg AC. Can Turn Duration and Step Parameters During the Timed Up and Go Test With and Without a Dual-Task Discriminate Between Individuals With Different Cognitive Abilities? An Explorative Study. Assessment. 2026 Jan 22:10731911251410337. doi: 10.1177/10731911251410337. Online ahead of print. PMID 41572419
  • Lofgren N, Berglund L, Giedraitis V, Halvorsen K, Rosendahl E, McKee KJ, Aberg AC. Extracted step parameters during the timed up and go test discriminate between groups with different levels of cognitive ability-a cross-sectional study. BMC Geriatr. 2025 Mar 17;25(1):182. doi: 10.1186/s12877-025-05828-6. PMID 40097949
  • Aberg AC, Petersson JR, Giedraitis V, McKee KJ, Rosendahl E, Halvorsen K, Berglund L. Prediction of conversion to dementia disorders based on timed up and go dual-task test verbal and motor outcomes: a five-year prospective memory-clinic-based study. BMC Geriatr. 2023 Sep 2;23(1):535. doi: 10.1186/s12877-023-04262-w. PMID 37660032

Identifiers

NCT: NCT05893524 · HDA2021-00022 · PUBCARE2016_122

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗