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Recruiting NCT05890599

Yoga Versus Health Education for the Treatment of Persistent Fatigue in Patients With Post COVID-19 Syndrome

No phase Interventional Post-COVID-19 Syndrome Fatigue Post Viral

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Yoga Therapy, Health Education.
Who it may be relevant to
Registry conditions: Post-COVID-19 Syndrome, Fatigue Post Viral. Basic parameters: 18 years — 65 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Germany
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Randomized Multicenter Clinical Trial: Yoga Versus Health Education for the Treatment of Persistent Fatigue in Patients With Post COVID-19 Syndrome

Overview

Evaluation of the short- and medium-term effect of a yoga intervention in addition to routine care compared to health education in addition to routine care on fatigue in patients with post covid syndrome.

Interventions

  • Behavioral Yoga Therapy
    The range of interventions is based on previous studies on yoga interventions specifically for fatigue patients as well as on recommendations, for example, from the WHO. The yoga therapy includes 3 elements: yoga postures (asanas), breathing techniques (pranayama) and relaxation moments. Emphasis on postures and breathing techniques that are considered to be effective for fatigue symptoms, as well as specific breathing exercises to strengthen the respiratory muscles and increase lung volume.
  • Behavioral Health Education
    Health education courses are conducted on-site once a week for 90 minutes over a 12-week period by a psychologist with clinical experience. The courses are didactic in nature and consist of lectures on topics of interest to patients with post-COVID syndrome and fatigue, followed by questions and discussion sessions. Topics include information on post-COVID syndrome and fatigue, an introduction to self-help for post-viral symptoms, psychosocial problems and fatigue, relaxation and stress manageme

Primary outcome measures

  • Fatigue [Time frame: 12 weeks]
Secondary outcome measures (12)
  • Fatigue [Time frame: 24 weeks]
  • Health related quality of life SF-12 [Time frame: 12 weeks]
  • Health related quality of life SF-12 [Time frame: 24 weeks]
  • Health related quality of life EQ-5D-5L [Time frame: 12 weeks]
  • Health related quality of life EQ-5D-5L [Time frame: 24 weeks]
  • Psychological symptoms [Time frame: 12 weeks]
  • Psychological symptoms [Time frame: 24 weeks]
  • Sleep quality [Time frame: 12 weeks]
  • Sleep quality [Time frame: 24 weeks]
  • Stress [Time frame: 12 weeks]
  • Stress [Time frame: 24 weeks]
  • Post-exertional malaise [Time frame: 12 weeks]

Eligibility criteria

Inclusion criteria

  • Confirmed COVID-19 diagnosis
  • Follow-up symptoms of ≥ 12 weeks
  • Persistent fatigue (scores ≥4 on the binomial Chalder Fatigue Scale).
  • Self-assessment that fatigue was a consequence of COVID-19 disease
  • Age 18-65 years

Exclusion criteria

  • Chronic medical conditions or regular use of medications associated with fatigue
  • Indication of health cause of fatigue other than post-COVID.
  • Indication of other factors as the main cause of fatigue
  • Physical limitations that do not allow participation in the yoga intervention
  • Pregnancy, breastfeeding
  • Concurrent participation in other clinical trials
  • Current yoga practice

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Single blind
Primary purpose
Treatment

Study locations

Germany · 1 center
  • Bosch-Health-Campus — Stuttgart

Publications

  • Cramer H, Morchen L, Vagedes J, Klenk J, Jager S, Schleinzer A, Anheyer D, Bilc M, Schroter M, Kessler C, Jeitler M. Yoga versus health education for persistent fatigue in patients with post-COVID-19 syndrome: protocol for a multicentre randomised controlled trial. BMJ Open. 2025 Oct 23;15(10):e107840. doi: 10.1136/bmjopen-2025-107840. PMID 41130694

Identifiers

NCT: NCT05890599 · S00766-RBK

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗