BACTERIUM: Study for a Machine-learning-based Model to Predict Bloodstream Infections
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: antibiotic treatments.
- Who it may be relevant to
- Registry conditions: Infection, Bloodstream. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Italy
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
An increase of healthcare-associated infections caused by multidrug- resistant organisms (MRDO) is currently observed. One of the main causes of the emergence of a MDRO infection is an overuse of antibiotics. Therefore, saving useless antibiotic treatment is currently a priority from a public health point of view. The evaluation of the risk of having a bloodstream infection will allow both activating faster treatment decisions (when the risk is significantly high) or to save useless resources in terms of diagnostic tests and treatments, also limiting the potential for side effects (when the risk is significantly low).
Interventions
- Drug antibiotic treatments
The outcome of the study will be to implement Prediction Models to support clinicians for the assessment of risk of having a bloodstream infection.
Primary outcome measures
- Rate of appropriate antibiotic therapy in patients with bloodstream infections [Time frame: 24 months]
- Blood cultures [Time frame: 24 months]
Eligibility criteria
Inclusion criteria
- adult patients hospitalized at the Gemelli Polyclinic Foundation
- having at least one performed blood culture
- starting an antibiotic therapy
Exclusion criteria
- blood cultures with contaminants
- <18 years old
- died after less than 48 hours from blood cultures positivity
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Italy · 1 center
- Fondazione Policlinico Agostino Gemelli Irccs — Rome
Identifiers
NCT: NCT05876598 · BACTERIUM-4407