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Enrolling by invitation NCT05876169

How Does Orthognathic Surgery Affect Jaw and Neck Motor Function?

No phase Interventional Cleft Lip and Palate

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Orthognathic surgery.
Who it may be relevant to
Registry conditions: Cleft Lip and Palate. Basic parameters: 16 years — 50 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Sweden
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Overview

In a prospective longitudinal study design, details in jaw-neck kinematics and electromyography (EMG) activity changes in patients (women and men) referred for surgical correction of basal relations between the maxilla and mandible over time; pre-operative and during follow-up 8 weeks and 18 months after surgical correction will be evaluated. The results will contribute with novel insights on jaw-neck motor function before, in short- and long-term after the surgical process. We will have blinded evaluation of outcomes.

Detailed description

Consecutive patients referred to department of Oral and Maxillofacial Surgery, Umeå University Hospital for corrective maxillofacial-mandibular surgery, will offer opportunity to be included in the study. Expected number of patients: 20 - 25 patients annually. Blinded evaluation will be pre-operative and during follow-up 8 weeks and 18 months after surgical correction.

Interventions

  • Procedure Orthognathic surgery
    Surgical corrections of the maxilla and/or the mandible. Integrated jaw-neck movement patterns, muscle activity, bite force and occlusal contact area will be registered and mapped with quantitative objective functional variables. The state-of-the-art core equipment to evaluate jaw-neck motor function in detail is located in the Movement Lab (Department of Odontology, Umeå University).

Primary outcome measures

  • Change in Kinematic outcome variables [Time frame: Preoperatively, postoperatively 8 weeks, 18 months]
  • Change in Kinematic outcome variables [Time frame: Preoperatively, postoperatively 8 weeks, 18 months]
  • Change in Kinematic outcome variables [Time frame: Preoperatively, postoperatively 8 weeks, 18 months]
  • Change in Kinematic outcome variables [Time frame: Preoperatively, postoperatively 8 weeks, 18 months]
  • Change in Kinematic outcome variables [Time frame: Preoperatively, postoperatively 8 weeks, 18 months]
  • Change in Electromyography (EMG) [Time frame: Preoperatively, postoperatively 8 weeks, 18 months]
  • Change in Maximum voluntary occlusal bite force (MVOBF) [Time frame: Preoperatively, postoperatively 8 weeks, 18 months]
  • Change in Occlusal contact area [Time frame: Preoperatively, postoperatively 8 weeks, 18 months]

Eligibility criteria

Inclusion Criterias:

  • Patients accepted for orthognathic surgery due to jaw discrepancies.
  • Patients given their consent for participation

Exclusion Criterias:

  • Patients with syndromes
  • Patients not given their consent for participation
  • Patients unable to follow instructions due to lack of knowledge in Swedish and/or English language

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
N/A
Model
Single group
Masking
Open label
Primary purpose
Treatment

Study locations

Sweden · 1 center
  • Faculty of Medicine, Department of Odontology, Umeå University — Umeå

Identifiers

NCT: NCT05876169 · 2022-kakfunktion

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗