Recruiting NCT05843604

Cerebral and Cognitive Markers of Treatment Resistance in Obsessive Compulsive Disorder

— Observational OCD

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied: The protocol lists: Functional MRI.
Who it may be relevant to: Registry conditions: OCD. Basic parameters: 18 years — 70 years · All.
What needs checking: Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place: France
Next step: Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Official title

Cerebral and Cognitive Markers of Treatment Resistance in Obsessive-compulsive Disorder: Towards Personalization of Patient Care

This study aims to define individual profiles of treatment resistants in order to find indicators and predictors of the therapeutic response.

Other Functional MRI
Three cognitive tests will be performed in the MRI, namely a stroop task, an N-back task and a switching task

Cerebral activity modification during N-back task [Time frame: Day 1]
Cerebral activity modification during Stroop task [Time frame: Day 1]
Cerebral activity modification during switching task (Monsell et Mizon task ) [Time frame: Day 1]

Obsessive compulsive disorder diagnosed according to Diagnostic and Statistical Manual 5 criteria (patients will be included regardless of the severity and resistance of their pathology and their levels of executive functions)
Understand and accept the constraints of the study
Be a beneficiary or affiliated to a Health Insurance scheme

Present one of the diagnoses according to the criteria of the DSM 5: schizophrenic disorders, substance abuse or dependence to a substance according to the criteria of the M.I.N.I. version 5.0 (Sheehan et al., 1998)
Generalized anxiety disorder, social anxiety, nicotine dependence and history of a major depressive episode are not exclusion criteria according to the M.I.N.I. version 5.0 (Sheehan et al., 1998)
Have a serious intercurrent pathology
Being a pregnant woman
Being a woman of childbearing age without effective contraception.
Being hospitalized under duress or on an outpatient basis in a care program
Being under judicial protection (reinforced curatorship, guardianship)

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

France · 1 center

NCT: NCT05843604 · 2022-A00463-40