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Recruiting NCT05835817

Magnetoencephalography by Optical Pumping Magnetometer

No phase Interventional Magnetoencephalography Optical Pump Magnetometer Neonate Premature

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Magnetoencephalography.
Who it may be relevant to
Registry conditions: Magnetoencephalography, Optical Pump Magnetometer, Neonate, Premature. Basic parameters: from 1 Day · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
France
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Overview

MagnetoEncephaloGraphy (MEG) is a method of recording brain activity with high temporal resolution and good spatial resolution, compared to current recording techniques such as ElectroEncephaloGraphy (EEG). The main limitation of MEG is its cost due to the sensors used, the Super Quantum Interference Devices (SQUID). These require a complex infrastructure from an instrumentation point of view to operate, requiring liquid helium, most often at a loss, at increasing cost. Optical Pumping Magnetometers (OPM) type sensors represent a promising alternative to SQUIDs sensors, especially since they do not require helium cooling. The purpose of this project is to Identify biomarkers in Magnetoencephalography of normal brain development in healthy adults, premature and term newborns from "a priori" obtained by the classical technique of High Resolution EEG performed.

Interventions

  • Other Magnetoencephalography
    40 minutes of Magnetoencephalography with Optical Pump Magnetometer

Primary outcome measures

  • Signal to noise ratio of the MEG OPM [Time frame: 1 day]
  • Signal to noise ratio of HR EEG [Time frame: 1 day]
  • Number of dB between Signal to noise ratio of the MEG OPM and Signal to noise ratio of HR EEG [Time frame: 1 day]

Eligibility criteria

Inclusion criteria

  • For healthy adult volunteers
  • Age between 18 and 65
  • No pathology, no treatment
  • No toxicant intake
  • For term newborns
  • Child between 38 and 42 weeks gestational age on the day of registration
  • No pathology, no treatment
  • For children born prematurely
  • Child between 28 and 36 weeks gestational age on the day of registration
  • No pathology, no treatment apart from routine care related to prematurity
  • For pregnant women
  • Pregnant with between 28 to 40 weeks gestational age on the day of registration
  • No pathology, no treatment

Exclusion criteria

  • Subject and Patients "not compatible" MEG. Wearers of prosthesis or pacemaker likely to generate artefacts interfering with the measurement. There is no danger to the subject, but the measurement itself may be impossible.
  • Patients who cannot stand to stand still for a few minutes.
  • Newborn on ventilatory assistance or infusion
  • Newborn baby not meeting the age criteria

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
Non-randomized
Model
Parallel assignment
Masking
Single blind
Primary purpose
Other

Study locations

France · 1 center
  • CHU Amiens — Amiens

Identifiers

NCT: NCT05835817 · PI2021_843_0205

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗