PET-MRI Esophagus Feasibility Study
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: PET-MRI.
- Who it may be relevant to
- Registry conditions: Esophagogastric Cancer. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Canada
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Feasibility Study of PET-MRI as a Platform for Image Guidance and Adaptive Radiation Therapy in Patients With Esophagogastric Cancer
Overview
This is a single arm, single centre, investigator initiated study to investigate the feasibility of using PET-MRI imaging in radiation treatment workflow in up to 15 patients with esophagogastric cancer. PET-MRI imaging will be completed before the start of radiation treatment. MRI imaging will be completed during radiation treatment and after radiation treatment. These images will not be used to plan the radiation treatment and routine clinical care will be provided. The goal of this study is to gather information that will allow the radiation team to include MRI and PET imaging into the radiation treatment workflow for patients with esophageal cancer receiving radiation therapy in the future.
Interventions
- Procedure PET-MRI
A PET/MRI scan is a two-in-one test that combines images from a positron emission tomography (PET) scan and a magnetic resonance imaging (MRI) scan. Magnetic Resonance Imaging (MRI) provides better soft tissue contrast compared to conventional computerized tomography (CT), and when combined with PET, can potentially provide better visualization of the tumor shape, size, and position. Additional MRI imaging will be completed once during radiation treatment, and once after radiation treatment
Primary outcome measures
- Feasibility of PET-MRI to visualize and assess impact of RT treatments on esophagogastric tumors [Time frame: 2 years]
Secondary outcome measures (2)
- Difference in manual GTV segmentation using PET-MRI [Time frame: 2 years]
- Quantification of dosimetric advantages of PET-MRI treatment plan [Time frame: 2 years]
Eligibility criteria
Inclusion criteria
- Patients 18 years or older
- Diagnosed with locally advanced esophageal cancer being considered for conventional RT >4 weeks
- Ability and willingness to provide written informed consent
Exclusion criteria
- Contraindication for MRI
- Contraindication for Gadolinium (i.e. inability to lie supine for at least 60 minutes)
- Any patient who is pregnant or breastfeeding
- Pacemaker or implanted defibrillator
- Claustrophobia
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Health services research
Study locations
Canada · 1 center
- Princess Margaret Cancer Centre — Toronto
Identifiers
NCT: NCT05796102 · 22-5780