Observational, Prospective, Cohort Study of Mpox Infection in Brazil (NETPOX)
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Viral genomic, Untargeted Metabolomics.
- Who it may be relevant to
- Registry conditions: Monkeypox, MPOX. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Brazil
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Observational, Prospective, Cohort Study of Mpox Infection in Brazil - NETPOX Cohort
Overview
The study is a prospective cohort that evaluates the clinical and immune-metabolic variables that may be linked to the risk and severity of the infection or even hospitalization or death in patients infected with the Mpox virus in Brazil. The expectation is to include at least 80 patients over six months, with a follow-up of 90 days from inclusion, through contact via decentralized visits.
Interventions
- Diagnostic test Viral genomic
Evaluation of mpox viral genomic - Diagnostic test Untargeted Metabolomics
Evaluation of metabolomics of the total plasma, oropharynx, and skin samples.
Primary outcome measures
- Composed of incidence of rash, fever, adenopathy, general pain, chills, weakness, occurrence of hospitalization, and neurological repercussions [Time frame: Up to 90 days after the inclusion]
Secondary outcome measures (4)
- Death [Time frame: Up to 90 days after the inclusion]
- Hospitalizations [Time frame: Days 15, 30, 60, and 90]
- Untargeted metabolomics of total plasmas and skin lesion [Time frame: Days 15, 30, 60, and 90]
- Viral genomic [Time frame: Day 0]
Eligibility criteria
Inclusion criteria
- Men and women aged ≥ 18 years with confirmed MPOX infection.
(laboratory-confirmed monkeypox infection is defined as determined by PCR, culture, or antigen test obtained from a sample collected from blood, oropharynx, anal or skin lesion within 4 days of randomization)
Exclusion criteria
- Inability to provide informed consent;
- Patient who, judging by the study team, does not have a condition for decentralized follow-up
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Brazil · 3 centers
- Hospital Universitário João de Barros Barreto — Belém
- Hospital Israelita Albert Einstein — São Paulo
- Hospital Naval Marcílio Dias — Rio de Janeiro
Identifiers
NCT: NCT05784038 · NETPOX