Exercise to Slow Cardiovascular Ageing Progression
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Cardiac Ageing, Exercise, Cardiovascular. Basic parameters: 21 years — 100 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Singapore
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
In ageing, deleterious alterations in cardiovascular (CV) structure and function increase risks of ageing-related cardiovascular disease (CVD). Investigators found that these CV alterations were associated with circulating serum metabolites, suggesting a metabolic basis to CV ageing. Investigators hypothesize that modification of these metabolites by intervention, such as exercise, may retard CV alterations and reduce CVD in ageing.
Detailed description
Participants from each stratum will be randomized to receive either an exercise program intervention or no exercise. At the start and end of study, participants will undergo cardiovascular imaging and metabolic profiling. Investigators will determine if exercise can reverse high-risk metabolic profiles and improve cardiovascular structure and function.
Without clear mechanisms to explain cardiovascular ageing nor interventions known to retard cardiovascular ageing, our approach will provide much needed translational evidence to incorporate targeted interventions aimed at reducing cardiovascular disease risk in older populations.
Primary outcome measures
- Metabolite profiles [Time frame: 12 Months]
- Cardiovascular structure and function [Time frame: 12 Months]
Eligibility criteria
Inclusion criteria
- Age >=21 years old
- Outdoor ambulant
Exclusion criteria
- Wheelchair or bed-bound
- Dementia
- Residing in sheltered or nursing home
- Cancer
- Participation in ongoing clinical trials that involve interventional drugs or devices
- Aneurysms
- Acute infections (in the last six months)
- Uncontrolled thyrotoxicosis
- Neuromuscular, musculoskeletal or rheumatoid disorders that are exacerbated by exercise
- Uncontrolled asthma or chronic lung disease
- Restrictive lung disease
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
Singapore · 1 center
- National Heart Centre Singapore — Singapore
Identifiers
NCT: NCT05775484 · 2022/2667