The Association Between the Intraoperative Blood Pressure Changes and Whole Exome Genome
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In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: this study did not involve interventions; it only observational study.
- Who it may be relevant to
- Registry conditions: the Association Between the Arterial Stiffness, Intraoperative Blood Pressure Changes and Genetic Effect. Basic parameters: 20 years — 90 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Association Between Whole Exon Sequencing and Arterial Stiffness in Patients With Intraoperative Hypotension)
Overview
The intraoperative blood pressure changes have been important for postoperative morbidity and mortality. However, some patients did not occur intraoperative hypotension but some patients would have severe intraoperative hypotension. It may be associated with genome related. In this hypothesis, we aim to elucidate the association between the whole exome genome and intraoperaive blood pressure changes.
Detailed description
We aim to elucidate the association between the whole exome genome and intraoperative blood pressure changes.
We will enroll patients older than 20 years old and undergo elective general anesthesia.
Before anesthesia, we will obtain blood sample for whole exome genome test and give arterial line for intraoperative monitor.
After completing surgery, we will follow the patients' all postoperative major organ function.
We hope this study to be able to give us the more information about the specific genetic effect on the arterial stiffness and intraoperative blood pressure changes.
Interventions
- Other this study did not involve interventions; it only observational study
this study did not involve interventions. This study is an observational study for elucidating the intraoperative blood pressure changes, artierial stiffness, and whole exome genome
Primary outcome measures
- The association between the arterial stiffness and whole exome genome [Time frame: 15 minutes]
Eligibility criteria
Inclusion criteria
- elective general surgery
Exclusion criteria
- coagulopathy
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Case-control
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT05730140 · 202209125RINC