Histopathological Analysis of Renal Biopsies With Dynamic Full-field Optical Coherence Tomography, a Comparison to Conventional Histopathological Findings for the Diagnosis of Either Acute Kidney Injury or Chronic Kidney Disease in Routine Practices (NEPHROCT)
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In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Dynamic full-field optical coherence tomography analysis of kidney biopsy.
- Who it may be relevant to
- Registry conditions: Acute Kidney Injury, Chronic Kidney Diseases, Tomography, Optical Coherence. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Histopathological Analysis of Renal Biopsies With Dynamic Full-field Optical Coherence Tomography, a Comparison to Conventional Histopathological Findings for the Diagnosis of Either Acute Kidney Injury or Chronic Kidney Disease in Routine Practices
Overview
Kidney biopsy play a key role for the investigation of either acute kidney injury or chronic kidney disease. Despite possible complications due to the invasive nature of the biopsy, such procedure is still essential in a number of clinical situations to improve the diagnosis specificity of kidney disease, better inform about its prognosis and guide the management of a future treatment. Pursuing the idea to improve both performance and rapidity associated with the histopathological analysis of kidney biopsy, with a possible recourse to artificial intelligence-based renal pathology, the present study intends to assess the impact of direct histopathological examination of kidney biopsy with dynamic full-field optical coherence tomography in routine practices for the diagnosis of either acute kidney injury or chronic kidney disease.
Interventions
- Other Dynamic full-field optical coherence tomography analysis of kidney biopsy
Dynamic full-field optical coherence tomography analysis of kidney biopsy in the nephrology department before conventional histopathological analysis
Primary outcome measures
- Histopathological analysis of elementary lesions in nephropathology with dynamic full-field optical coherence tomography [Time frame: Outcome measure is assessed 15 days following kidney biopsy]
Secondary outcome measures (1)
- Histopathological analysis of healthy kidney biopsy with dynamic full-field optical coherence tomography [Time frame: Outcome measure is assessed 15 days following kidney biopsy]
Eligibility criteria
Inclusion criteria
- patients > 18 years of age with suspected acute kidney injury requiring biopsy in the nephrology department
- patients > 18 years of age with suspected chronic kidney disease requiring biopsy in the nephrology department
Exclusion criteria
- inability to perform dynamic full-field optical coherence tomography observation at the moment of kidney biopsy
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Other
Study locations
France · 1 center
- Centre Hospitalier William Morey - Chalon sur Saône — Chalon-sur-Saône
Publications
- Hull KL, Adenwalla SF, Topham P, Graham-Brown MP. Indications and considerations for kidney biopsy: an overview of clinical considerations for the non-specialist. Clin Med (Lond). 2022 Jan;22(1):34-40. doi: 10.7861/clinmed.2021-0472. Epub 2021 Dec 17. PMID 34921054
- Jain M, Robinson BD, Salamoon B, Thouvenin O, Boccara C, Mukherjee S. Rapid evaluation of fresh ex vivo kidney tissue with full-field optical coherence tomography. J Pathol Inform. 2015 Sep 28;6:53. doi: 10.4103/2153-3539.166014. eCollection 2015. PMID 26605118
Identifiers
NCT: NCT05728216 · NEPHROCT