Volatile Non-Invasive Biomarkers of Epileptic Seizures
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Sample Collection.
- Who it may be relevant to
- Registry conditions: Epilepsy, Non-Epileptic Seizure. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United Kingdom
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Breath and sweat samples will be collected from people who have been admitted to hospital after a potential seizure and analysed by the team. The researchers then hope to identify a pattern of small molecules that can distinguish seizures from other events, and perhaps determine the severity of the seizure.
Detailed description
Determining whether someone has had an epileptic seizure, or another event, can be challenging and result in the wrong diagnosis. A 'seizure test' used after the event would therefore be very helpful.
Researchers have used small molecules released from the body in breath and sweat to detect cancers and other diseases; this study will determine whether a similar method can be used to detect whether someone has had an epileptic seizure.
Interventions
- Other Sample Collection
Patients will have breath samples collected by blowing into a bag, and sweat samples collected by gauze. These samples will be collected at various timepoints whilst the patients are admitted on the ward.
Primary outcome measures
- Distinguishing epileptic from non-epileptic seizures [Time frame: 3 years]
Eligibility criteria
Inclusion criteria
- Patients who have been admitted to either University College London's Queen's Square EEG-telemetry unit or Chalfont Centre for Epilepsy, for diagnosis of seizure events.
- Patients aged 18 years or above
Exclusion criteria
- Patients with active infection or who have taken antibiotics within 4 weeks
- Patients on immunosuppressive medications
- Patients with co-morbidities preventing breath collection
- Patients unable to provide informed consent.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
United Kingdom · 2 centers
- Chalfont Centre for Epilepsy — London
- National Hospital for Neurology and Neurosurgery — London
Identifiers
NCT: NCT05725174 · 285913 · 22/LO/0808