Menu
Recruiting NCT05724641

Arterial Spin Labeling MRI for Assessing Blood Perfusion in the Human Eye Repeatability Study and Clinical Application

No phase Interventional Retinal Diseases

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: MRI perfusion imaging using ASL's non-invasive technique.
Who it may be relevant to
Registry conditions: Retinal Diseases. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Belgium
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Overview

The MRI perfusion imaging using arterial spin labeling (ASL)'s non-invasive technique (i.e. without injection of contrast medium) allows, thanks to recent technological improvement of the spatial resolution, measuring several perfusion parameter of the retinal tissue such as the regional Blood Flow (rBF) or the cerebral blood flow (cBF) expressed in ml/100g/min. Reliable application of ASL thus requires the precision and specificity of the MRI protocol to be tested.

Interventions

  • Diagnostic test MRI perfusion imaging using ASL's non-invasive technique
    Patients will undergo through an MRI-scan using the ASL MRI sequence, as described per protocol.

Primary outcome measures

  • Repeatability measurement on volunteers [Time frame: 2 month]
Secondary outcome measures (2)
  • Mesurement of the retinal perfusion by MRI ASL in patient in acute phase [Time frame: 4 years]
  • Mesurement of the retinal perfusion by MRI ASLin patient in a chronic phase [Time frame: 4 years]

Eligibility criteria

Inclusion criteria

  • Carrier of target pathologies: TAO optic neuropathy, inflammatory optic neuropathy, ischemic optic neuropathy.
  • no cardiovascular risk factors or other ophthalmological pathology
  • adhere to the study protocol after reading the patient information document
  • signe the informed consent form to participate in the study
  • do not have any contraindications to an MRI examination

Exclusion criteria

  • Usual contraindications to MRI (Pacemaker, Metallic foreign body, Cochlear implant,…)
  • Severe claustrophobia

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
Non-randomized
Model
Parallel assignment
Masking
Open label
Primary purpose
Diagnostic

Study locations

Belgium · 1 center
  • Cliniques Universitaires Saint Luc — Brussels

Identifiers

NCT: NCT05724641 · CUSL-2022-PerfRet · 2022/06DEC/471

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗