Motivational Behavioral and Functional MRI Impairment in Patients With Chronic Neuropathic Pain
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: reward learning task.
- Who it may be relevant to
- Registry conditions: Chronic Pain. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The main hypothesis of this study is that the alteration of the reward circuitry underlying the motivational deficit in chronic pain patients compared to healthy subjects results in a decrease in the capacity for reward learning. The fMRI studies have shown that this type of learning depends on the dopaminergic system innervating key regions of the reward system.
Interventions
- Other reward learning task
during usual follow-up patients will complete a remard learning task questionnaire. This questionnaire cannot be assimilated to a clinical intervention.
Primary outcome measures
- To compare reward learning ability in patients with chronic neuropathic pain compared with an age (±5 years) and gender-matched control population [Time frame: Day 0]
Eligibility criteria
Inclusion criteria
- For cases: patients managed in the neurosurgery department or at CETD for chronic neuropathic pain, of central or peripheral origin.
- For controls: matched to a case on age (±5 years) and sex
Exclusion criteria
- Neurodegenerative or inflammatory neurological pathology
- Clinical depressive syndrome
- High doses of opioid treatment (greater than 100 mg/day of morphine equivalent)
- Impaired judgment or inability to receive information that does not allow the performance of behavioral tasks
- Absolute contraindication to MRI (e.g. pacemaker, implantable pacemaker, metallic intra-orbital foreign body)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-control
Study locations
France · 1 center
- Hôpital Fondation Adolphe de Rothschild — Paris
Identifiers
NCT: NCT05701852 · HBD_2022_6