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Recruiting NCT05699200

A Study to Analyze the Role of Sympathetic Nervous System in Spontaneous Coronary Artery Dissection

No phase Interventional Spontaneous Coronary Artery Dissection Healthy

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Arterial Tonometry, Echocardiogram, Carotid Ultrasounds, Elastography.
Who it may be relevant to
Registry conditions: Spontaneous Coronary Artery Dissection, Healthy. Basic parameters: from 18 years · Female.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United States
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Role of the Neurovascular System in Spontaneous Coronary Artery Dissection (SCAD)

Overview

The purpose of this research is to compare sympathetic function (flight or fight system) and arterial health including structure and mechanics of participants with history of spontaneous coronary artery dissection (SCAD) to age and sex matched control participants.

Interventions

  • Other Arterial Tonometry
    We will measure arterial stiffness using arterial tonometry.
  • Diagnostic test Echocardiogram
    We will collect limited ultrasound images of the heart.
  • Diagnostic test Carotid Ultrasounds
    We will perform ultrasound imaging of the carotid artery.
  • Diagnostic test Elastography
    We will measure the elastic properties of the arteries using elastography.
  • Other Ankle-Brachial Index
    We will measure the ankle-brachial index to assess peripheral artery blood flow.
  • Other Microneurography with sympathoexcitatory maneuvers
    We will measure sympathetic nerve activity at rest and in response to isometric handgrip, mental stress test, cold pressor test, Valsalva maneuvers.

Primary outcome measures

  • Arterial thickness [Time frame: Baseline]
  • Arterial stiffness [Time frame: Baseline]
  • Baroreflex sensitivity [Time frame: Baseline]
  • Sympathetic response to stress [Time frame: Baseline]

Eligibility criteria

Inclusion criteria

  • For SCAD patients: history of SCAD as confirmed by coronary angiography or cardiac computed tomography angiography
  • For controls: no cardiac disease history

Exclusion criteria

  • Pregnancy
  • Known or suspected unstable cardiac condition within 4 weeks of the study
  • Active treatment with anticoagulation or dual antiplatelet therapy
  • Prisoner

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
Non-randomized
Model
Parallel assignment
Masking
Open label
Primary purpose
Health services research

Study locations

United States · 1 center
  • Mayo Clinic Rochester — Rochester

Identifiers

NCT: NCT05699200 · 21-005636 · 1K23HL155506

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗