US and MRI of the Forefoot: Intermetatarsal Bursitis or Morton's Neuroma
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: MRI with contrast, Ultrasound.
- Who it may be relevant to
- Registry conditions: Intermetatarsal Bursitis, Morton Neuroma, Intermetatarsal Neuroma. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Denmark
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Ultrasound and MRI of the Forefoot: Intermetatarsal Bursitis or Morton's Neuroma
Overview
The aim of this study is to investigate the incidence of intermetatarsal bursitis and Morton's neuroma in patients with metatarsalgia (i.e. pain in the forefoot) and control subjects by diagnostic imaging with ultrasound and MRI.
Detailed description
In a group of patients with intermetatarsal pain found by an orthopedic surgeon, the investigators want to assess the incidences of intermetatarsal bursitis and Morton's neuroma, using diagnostic imaging; ultrasound and MRI.
The hypothesis is, that intermetatarsal bursitis is an overlooked diagnosis in patients with metatarsalgia. As a result of sparse literature and lack of knowledge about this condition with symptoms mimicking Morton's neuroma, a part of patients diagnosed with Morton's neuroma, suffers from intermetatarsal bursitis instead.
Additionally, the investigators want to evaluate the clinical sign opening toes.
Based on clinical photos of the feet, the investigators want to document the presence of opening toes and investigate if there is a correlation with either intermetatarsal bursitis and/or Morton's neuroma.
Interventions
- Diagnostic test MRI with contrast
MRI of the forefoot with contrast (Gadovist) - Diagnostic test Ultrasound
Ultrasound imaging of the forefoot
Primary outcome measures
- Incidence of intermetatarsal bursitis on MRI [Time frame: 8 weeks]
- Incidence of intermetatarsal bursitis on US [Time frame: 8 weeks]
- Incidence of Morton's neuroma on MRI [Time frame: 8 weeks]
- Incidence of Morton's neuroma on US [Time frame: 8 weeks]
- Incidence of other pathology on MRI [Time frame: 8 weeks]
- Incidence of other pathology on US [Time frame: 8 weeks]
- Incidence of normal findings on MRI [Time frame: 8 weeks]
- Incidence of normal findings on US [Time frame: 8 weeks]
Secondary outcome measures (1)
- Opening toes [Time frame: 8 weeks]
Eligibility criteria
Inclusion criteria
- Age > 18 years
- Pain in an intermetatarsal space (patient group)
Exclusion criteria
- Age <18 years
- Open wounds or ongoing infection in the forefoot at the time of examination
- Persons with contraindications to participate in MRI scan
- Persons with a history of significant trauma in the forefoot, e.g. any fracture or previous surgeries in the forefoot
- Persons who have previously received treatment for Morton's neuroma in the same foot, e.g. injection (within 6 months) or operation (anytime)
- Persons with severely impaired renal function (GFR <30 ml/min)
- Persons with a systemic inflammatory condition like rheumatoid arthritis, due to clinically silent intermetatarsal bursitis in this group (control group)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Non-randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Diagnostic
Study locations
Denmark · 1 center
- Department of Radiology — Copenhagen
Identifiers
NCT: NCT05685160 · H-20067346