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Recruiting NCT05683093

Cardiovascular Longitudinal ALSPAC Research Investigations Following Hypertensive Pregnancy in Young Adulthood

— Observational Young Adult Hypertension in Pregnancy Hypertension Cardiovascular Diseases

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: History of being born to hypertensive or normal pregnancy.
Who it may be relevant to
Registry conditions: Young Adult, Hypertension in Pregnancy, Hypertension, Cardiovascular Diseases. Basic parameters: 30 years — 40 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United Kingdom
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Cardiovascular Longitudinal the Avon Longitudinal Study of Parents and Children (ALSPAC) Research Investigations Following Hypertensive Pregnancy in Young Adulthood

Overview

The purpose of this study is to understand more about why young people who were born to a hypertensive pregnancy may have increased risk of high blood pressure and are often at increased risk of heart and blood vessel disease later in life.

Detailed description

Women who develop blood pressure problems during pregnancy are more likely to have high blood pressure (hypertension) in later life as well as heart attacks or strokes. The children born to the pregnancy also tend to have higher blood pressure and are often at increased risk of heart and blood vessel disease later in life. Previous work has shown that children born to pregnancies where the mother has high blood pressure have changes in their blood vessels, heart and brain that can be measured long before they develop high blood pressure or other clinical symptoms. By understanding the pattern of changes cross multiple parts of the body, over a lifetime, the investigators can identify how advanced the underlying disease is for an individual and how their disease is likely to develop over the next few years.

The aim of this study is to understand the heart and blood vessel changes of people born to a hypertensive pregnancy once they are in their 20s and 30s. The investigators then hope to use this information to develop new ways to prevent early onset heart and blood vessel disease in these people.

Interventions

  • Other History of being born to hypertensive or normal pregnancy
    CLARITY is an observational study whereby participants will attend one 4-hr visit the Division of Cardiovascular Medicine, University of Oxford at the John Radcliffe Hospital in Oxford, with the option to split the study visit over two days for convenience. Participants will be invited by the ALSPAC study team to attend a study visit in Oxford where the investigators will use MRI and other imaging modalities to study the brain, heart, liver, kidneys, and vasculature using standardised protocols

Primary outcome measures

  • Cardiac right ventricular mass [Time frame: 30-40 years of old]
Secondary outcome measures (12)
  • Cardiac left ventricular mass [Time frame: 30-40 years of old]
  • Cardiac right ventricular end-diastolic volume [Time frame: 30-40 years of old]
  • Cardiac right ventricular stroke volume [Time frame: 30-40 years of old]
  • Cardiac left ventricular end-diastolic volume [Time frame: 30-40 years of old]
  • Cardiac left ventricular stroke volume [Time frame: 30-40 years of old]
  • Cardiac right ventricular systolic function [Time frame: 30-40 years of old]
  • Cardiac left ventricular systolic function [Time frame: 30-40 years of old]
  • Cardiac right ventricular diastolic function [Time frame: 30-40 years of old]
  • Cardiac left ventricular diastolic function [Time frame: 30-40 years of old]
  • Morphology of the right ventricles [Time frame: 30-40 years of old]
  • Morphology of the left ventricles [Time frame: 30-40 years of old]
  • Aortic compliance [Time frame: 30-40 years of old]

Eligibility criteria

Inclusion criteria

  • Participant is willing and able to give informed consent for participation in the study
  • Male or female, aged 30 to 40 years at time of enrolment
  • Participant previously took part in the ALSPAC study
  • Able (in the investigator's opinion) and willing to comply with all study requirements
  • Adequate understanding of verbal and written English

Exclusion criteria

  • Pregnant or lactating when they are due to attend for study visit 1
  • Less than six months postpartum
  • Planning to donate blood within two weeks prior to study visit 1
  • Any significant disease or disorder which, in the opinion of the investigator, might influence the participant's ability to participate in the study
  • Evidence of congenital heart disease or significant chronic disease relevant to cardiovascular or metabolic status

For exclusion of MRI component only:

  • Unsuitable for MRI based on participant screening; the participant may still be included in other parts of the study

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model
Cohort

Study locations

United Kingdom · 1 center
  • University of Oxford — Oxford

Identifiers

NCT: NCT05683093 · 22/WA/0227

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗