A Study of Pressure Waveform Analysis in Coronary Artery-II
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: CFR and IMR group.
- Who it may be relevant to
- Registry conditions: Ischemic Heart Disease. Basic parameters: from 21 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Taiwan
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The goal of this observational study is to test the feasibility of intracoronary adenosine administration during coronary flow reserve(CFR) and index of microcirculatory resistance(IMR) assessment in a population with angina. The main questions it aims to answer are: * Repeatability of CFR and IMR assessment while hyperemia with intracoronary adenosine was administered. * Evaluate the correlation of the intrinsic signal of coronary waveform versus physiologic ischemia, while defined by fractional flow reserve(FFR) and CFR respectively. * The predictive value of FFR, CFR, and IMR on major adverse cardiovascular outcomes in 3 years Participants will undergo FFR, CFR, and IMR assessments in the catheterization laboratory of the National Taiwan University Hospital Hsin-Chu Branch, then clinical events follow up for 3 years.
Interventions
- Procedure CFR and IMR group
Participants will undergo repeat intracoronary adenosine administration during CFR and IMR measurement
Primary outcome measures
- Repeatability of CFR and IMR value [Time frame: 10 minutes]
Secondary outcome measures (1)
- Major adverse cardiovascular outcomes [Time frame: 3 year]
Eligibility criteria
Inclusion criteria
- Participants with angina
Exclusion criteria
- Severe valvular heart disease
- History of asthma
- Heart rate less than 50 beats per minute
- systolic blood pressure less than 90 mmHg
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Taiwan · 1 center
- National Taiwan University Hospital Hsin-Chu branch — Hsinchu
Identifiers
NCT: NCT05672706 · 111-129-E