Thrombus Imaging and Treatment Analytics in Neurology
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: thrombus imaging appearance.
- Who it may be relevant to
- Registry conditions: Thrombus, Brain, Thrombosis. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
In the present study, the investigators use high-resolution MR vessel wall imaging, and select patients with cerebral and cervical artery occlusion to investigate the relationship between the imaging appearance of thrombus and the various outcome of recanalization treatment.
Detailed description
Cerebral ischemic stroke resulting from thrombosis causes high disability and mortality. There are few biomarkers to evaluate arterial thrombophilia until now. Previous studies have demonstrated that atherosclerotic plaque rupture and erosion are major etiologies initiating thrombosis. Based on previous works targeting the role of plaque and blood flow in cerebrovascular disease, in the present study, the investigators use high-resolution MR vessel wall imaging, and select patients with cerebral and cervical artery occlusion to explore the relationship between the imaging appearance of thrombus and the various outcome of recanalization treatment. The study's objective was to solve the challenges in the mechanism of thrombus features and the outcome of recanalization therapy, thus helping improve the primary and secondary prevention of cerebrovascular disease.
Interventions
- Diagnostic test thrombus imaging appearance
Imaging appearance of intracranial and/or extracranial arterial thrombus
Primary outcome measures
- Rate of Successful Recanalization [Time frame: 1-3 Years]
- Ischemic Stroke Occurrence [Time frame: 1-3 Years]
Secondary outcome measures (1)
- Number of Participants with Adverse Events [Time frame: 1-3 Years]
Eligibility criteria
Inclusion criteria
- Age ≥ 18 years
- Extracranial and/or intracranial artery occlusion confirmed by angiography
- Available for magnetic resonance high-resolution vessel wall imaging
- Written informed consent obtained
Exclusion criteria
- Extracranial and/or intracranial artery mild to moderate stenosis
- Pregnant women
- Restenosis or occlusion after artery stenting placement
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Chinese PLA General Hospital — Beijing
Identifiers
NCT: NCT05663281 · 301Titan